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Details for messenger / hormone: IL-15

EndoNet ID: ENH00321

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Synonyms

  • Interleukin-15
  • IL-15
  • IL15
  • interleukin 15
  • IL 15

General information

  • Novel cytokine whose effects on T-cell activation and proliferation are similar to those of IL-2, presumably because IL-15 utilizes the beta and gamma chains of the IL-2 receptor. [1]
  • The numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2. [2]
  • Alternative splicing.

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    Sequence 
    NWVNVISDL KKIEDLIQS MHIDATLYT 
ESDVHPSCK VTAMKCFLL ELQVISLES 
GDASIHDTV ENLIILANN SLSSNGNVT 
ESGCKECEE LEEKNIKEF LQSFVHIVQ 
MFINTS

    Links to other resources

    UniProt P40933
    Ensembl ENST00000320650
    KEGG hsa:3600

    • Anatomical structure: bone_marrow

    • Anatomical structure: testis

    • Anatomical structure: colon

    • Anatomical structure: epidermis

    • Anatomical structure: placenta

    • Anatomical structure: skeleton_muscle

    • Anatomical structure: lung

    • Anatomical structure: kidney

    • Anatomical structure: heart

    • Anatomical structure: hepatocyte

    • Anatomical structure: monocyte

    • Anatomical structure: epithelial_cell

    Targets

    CellIL-15R alpha
    epithelial cell Present
    fibroblast Present
    keratinocyte Present
    macrophage Present
    monocyte Present
    nerve Present
    Reference