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Details for messenger / hormone: PDGFD

EndoNet ID: ENH00324

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Synonyms

  • spinal cord-derived growth factor B
  • iris-expressed growth factor
  • PDGFD
  • PDGF-D
  • PDGF D
  • platelet-derived growth factor D
  • iris-expressed growth factor long form
  • MSTP036
  • spinal cord-derived growth factor-B
  • IEGF
  • SCDGFB

General information

  • PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. [1]
  • Members of the PDGF family, such as PDGFD, are disulfide-bonded dimeric proteins involved in developmental and physiologic processes, as well as in cancer, fibrotic diseases, and arteriosclerosis. [2]
  • PDGF-D is a specific, protease-activated ligand for the PDGF beta-receptor. [3]

Classification

Hormone function

  • development and growth
    • growth stimulation
    • immune response
      • activation

      Chemical classification

      Composition

      platelet derived growth factor D isoform 1

      • See NP_079484 by NCBI.
      Sequence
      TPQSASIKA LRNANLRRD ESNHLTDLY 
      RRDETIQVK GNGYVQSPR FPNSYPRNL 
      LLTWRLHSQ ENTRIQLVF DNQFGLEEA 
      ENDICRYDF VEVEDISET STIIRGRWC 
      GHKEVPPRI KSRTNQIKI TFKSDDYFV 
      AKPGFKIYY SLLEDFQPA AASETNWES 
      VTSSISGVS YNSPSVTDP TLIADALDK 
      KIAEFDTVE DLLKYFNPE SWQEDLENM 
      YLDTPRYRG RSYHDRKSK VDLDRLNDD 
      AKRYSCTPR NYSVNIREE LKLANVVFF 
      PRCLLVQRC GGNCGCGTV NWRSCTCNS 
      GKTVKKYHE VLQFEPGHI KRRGRAKTM 
      ALVDIQLDH HERCDCICS SRPPR

      Platelet derived growth factor D, isoform 2

      • See NP_149126 by NCBI.
      Sequence
      NFCSCRDTS ATPQSASIK ALRNANLRR 
      DDLYRRDET IQVKGNGYV QSPRFPNSY 
      PRNLLLTWR LHSQENTRI QLVFDNQFG 
      LEEAENDIC RYDFVEVED ISETSTIIR 
      GRWCGHKEV PPRIKSRTN QIKITFKSD 
      DYFVAKPGF KIYYSLLED FQPAAASET 
      NWESVTSSI SGVSYNSPS VTDPTLIAD 
      ALDKKIAEF DTVEDLLKY FNPESWQED 
      LENMYLDTP RYRGRSYHD RKSKVDLDR 
      LNDDAKRYS CTPRNYSVN IREELKLAN 
      VVFFPRCLL VQRCGGNCG CGTVNWRSC 
      TCNSGKTVK KYHEVLQFE PGHIKRRGR 
      AKTMALVDI QLDHHERCD CICSSRPPR

      Links to other resources

      UniProt Q9GZP0
      Ensembl ENST00000393158
      KEGG hsa:80310
      • Anatomical structure: vascularendothelial_cell

      • Anatomical structure: epithelial_cell

      • Anatomical structure: kidney

      • Anatomical structure: smooth_muscle

      • Anatomical structure: orbit_right_and_left

        • Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial cell proliferation. [4]
      • Anatomical structure: aorta

      Targets

      CellPDGFRbeta
      lipocyte of liver Present
      Phenotypes
      • regulation of tissue remodeling
      Reference