Status
Please wait ...

Details for messenger / hormone: IL-2

EndoNet ID: ENH00325

To link to the content of EndoNet use the EndoNet ID that is given on the detail pages in the format ENX0000, where X is a place holder for the type of the component (e. g. R for receptor or C for anatomical structure).
As URL for the linking append this ID to the detail page for this type of component.
For an hormone that would be: 

http://endonet.bioinf.med.uni-goettingen.de/hormone/ENH00000

It is also possible to use the search of EndoNet to link to the right detail page. The URL should look like 

http://endonet.bioinf.med.uni-goettingen.de/search/ENC00000
If the search pattern is unambigious the user is directed to the corresponding detail page.

Synonyms

  • Interleukin-2
  • IL-2
  • IL2
  • IL 2
  • interleukin 2
  • T-cell growth factor
  • TCGF
  • Aldesleukin

General information

  • Uncontrolled secretion of IL-2 results in adverse reactions ranging from anergy, to aberrant T cell activation, to autoimmunity. [1]
  • The numbers of CD8+ memory T cells in animals are controlled by a balance between IL-15 and IL-2. [2]
  • Interleukin 2 regulates its own receptors. [3]
  • The lymphokine interleukin-2 (IL-2) is responsible for autocrine cell cycle progression and regulation of immune responses. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    Sequence 
    APTSSSTKK TQLQLEHLL LDLQMILNG 
INNYKNPKL TRMLTFKFY MPKKATELK 
HLQCLEEEL KPLEEVLNL AQSKNFHLR 
PRDLISNIN VIVLELKGS ETTFMCEYA 
DETATIVEF LNRWITFCQ SIISTLT

    Links to other resources

    UniProt P60568
    Ensembl ENST00000226730
    KEGG hsa:3558

    • Anatomical structure: blood

    • Anatomical structure: placenta

    • Anatomical structure: lymphocyte

    • Anatomical structure: T-lymphocyte

    • Anatomical structure: helper_T_cell_Th1

      • T-helper cells (Th1) produce interleukin (IL) -2 and interferon-gamma (IFN-gamma). [4]

      Influenced by:

      • CD28
        in helper_T_cell_Th1
        • CD28 is the primary co-stimulatory receptor for inducing high-level IL-2 production and survival of naive CD4(+) T cells. [5]

    Targets

    Reference