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Details for messenger / hormone: IL-5

EndoNet ID: ENH00327

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Synonyms

  • TRF
  • IL 5
  • B-cell differentiation factor I
  • Interleukin-5
  • eosinophil differentiation factor
  • B cell differentiation factor I
  • T-cell replacing factor
  • IL-5
  • IL5
  • interleukin 5
  • EDF

General information

  • The activity of IL5 in the human system, in contrast to IL3 and GM-CSF, is mainly limited to eosinophils and basophils. A likely explanation is the cell type-specific expression of the IL5Ralpha chain. [1]
  • The interleukine-5 (IL-5) is a hormone of the immune system that is the main regulator of eosinopoiesis, eosinophil maturation and activation, and immunoglobulin A production. [2]
  • Interleukin-5 (IL-5) is a potential candidate gene in the pathogenesis of asthma, as it is the main cytokine controlling eosinophil activity and eosinophils are pivotal in the development of airway inflammation. [3]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    Sequence 
    IPTEIPTSA LVKETLALL STHRTLLIA 
NETLRIPVP VHKNHQLCT EEIFQGIGT 
LESQTVQGG TVERLFKNL SLIKKYIDG 
QKKKCGEER RRVNQFLDY LQEFLGVMN 
TEWIIES

    Links to other resources

    UniProt P05113
    Ensembl ENST00000231454
    KEGG hsa:3567

    • Anatomical structure: T-lymphocyte

    • Anatomical structure: peripheral blood mononuclear cell (PBMC)

      • IL-5 production by PBMC upon stimulation with house dust mite (HDM) in patients with atopic dermatitis (AD) was significantly higher than that in non-atopic controls. [4]

    • Anatomical structure: helper_T_cell_Th2

    • Anatomical structure: helper_T_cell_Th2

    Targets

    Reference