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Details for messenger / hormone: IP-10

EndoNet ID: ENH00329

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Synonyms

  • IP-10
  • 10 kDa interferon gamma-induced protein
  • small-inducible cytokine B10
  • C-X-C motif chemokine 10
  • INP10
  • interferon-gamma induced protein
  • SCYB10
  • chemokine, CXC motif, ligand 10
  • interferon-gamma-inducible protein 10
  • IP10
  • small inducible cytokine B10
  • CXCL10
  • 10 kDa interferon-gamma-induced protein
  • Gamma-IP10
  • IFI10
  • interferon-gamma-induced factor
  • homolog of mouse MOB1
  • chemokine (C-X-C motif) ligand 10

General information

  • IP-10, a member of the alpha chemokine family, inhibits bone marrow colony formation, has antitumor activity in vivo, is chemoattractant for human monocytes and T cells, and promotes T cell adhesion to endothelial cells. [1]
  • IFN-gamma-inducible protein-10 (IP-10; CXCL10), a CXCR3 ligand that selectively recruits activated Th1 lymphocytes and NK cells, has been implicated recently in modulating airway inflammation in asthma. [2]

Classification

Hormone function

  • development and growth
    • growth inhibition
    • immune response
      • activation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • chemokines
              • CXC chemokines

        Composition

        Sequence 
        VPLSRTVRC TCISISNQP VNPRSLEKL 
EIIPASQFC PRVEIIATM KKKGEKRCL 
NPESKAIKN LLKAVSKER SKRSP

        Links to other resources

        UniProt P02778
        Ensembl ENST00000306602
        KEGG hsa:3627

        • Anatomical structure: prostate

        • Anatomical structure: keratinocyte

        • Anatomical structure: monocyte

        • Anatomical structure: dendritic_cell_in_lymphoid_tissues

        • Anatomical structure: macrophage

        Targets

        Reference