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Details for messenger / hormone: CXCL11

EndoNet ID: ENH00331

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Synonyms

  • small inducible cytokine B11
  • interferon gamma-inducible protein 9
  • small-inducible cytokine B11
  • C-X-C motif chemokine 11
  • I-TAC
  • CXCL11
  • interferon-inducible T-cell alpha chemoattractant
  • interferon-gamma-inducible protein 9
  • IP-9
  • H174
  • Beta-R1
  • SCYB11
  • SCYB9B
  • IP9
  • chemokine, CXC motif, ligand 11

General information

  • Chemotactive for interleukin-activated T cells but not unstimulated T cells, neutrophils or monocytes. [1]
  • IFN-gamma is a potent inducer of CXCL 11 transcription, which is synergistically enhanced by TNF-alpha. [2]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CXC chemokines

      Composition

      Sequence
      FPMFKRGRC LCIGPGVKA VKVADIEKA 
      SIMYPSNNC DKIEVIITL KENKGQRCL 
      NPKSKQARL IIKKVERKN F

      Links to other resources

      UniProt O14625
      Ensembl ENST00000306621
      KEGG hsa:6373
      • Anatomical structure: astrocyte

      • Anatomical structure: keratinocyte

      • Anatomical structure: bone_marrow

      • Anatomical structure: pancreas

      • Anatomical structure: leukocyte

      • Anatomical structure: lung

      • Anatomical structure: spleen

      • Anatomical structure: thymus

      • Anatomical structure: small_intestine

      • Anatomical structure: prostate

      • Anatomical structure: placenta

      • Anatomical structure: monocyte

        Influenced by:

        • IFNAR2
          in monocyte
          • Induction of CXCL11 by interferon beta. [3]
        • IFNGR1
          in monocyte
          • Induction of CXCL11 by IFN-gamma is enhanced by TNF-alpha in monocytes. [3]

      Targets

      CellCXCR3
      killer cell Present
      monocyte Present
      Reference