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Details for messenger / hormone: MCP-2

EndoNet ID: ENH00333

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Synonyms

  • small-inducible cytokine A8
  • C-C motif chemokine 8
  • MCP-2
  • CCL8
  • small inducible cytokine A8
  • monocyte chemotactic protein 2
  • monocyte chemoattractant protein 2
  • HC14
  • MCP2
  • chemokine, CC motif, ligand 8
  • SCYA8

General information

  • MCP-2 stimulates the directional migration of T cells as well as monocytes. [1]
  • Monocyte chemotactic proteins (MCPs) form a subfamily of chemokines that recruit leukocytes to sites of inflammation and that may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [2]
  • MCP-2 and the chemokine receptor 2 are critical for monocyte mobilization. [3]
  • Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils.

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      Sequence 
      QPDSVSIPI TCCFNVINR KIPIQRLES 
YTRITNIQC PKEAVIFKT KRGKEVCAD 
PKERWVRDS MKHLDQIFQ NLKP

      Links to other resources

      UniProt P80075
      Ensembl ENST00000394620
      KEGG hsa:6355

      • Anatomical structure: bone_marrow

      • Anatomical structure: small_intestine

      • Anatomical structure: blood

      • Anatomical structure: heart

      • Anatomical structure: placenta

      • Anatomical structure: lung

      • Anatomical structure: skeleton_muscle

      • Anatomical structure: thymus

      • Anatomical structure: colon

      • Anatomical structure: ovary

      • Anatomical structure: pancreas

      • Anatomical structure: brain

      • Anatomical structure: spleen

      • Anatomical structure: prostate

      • Anatomical structure: monocyte

      Targets

      CellCCR11
      No records found.
      Reference