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Details for messenger / hormone: TXA2

EndoNet ID: ENH00337

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Synonyms

  • TXA2
  • thromboxane A2
  • 9S,11S-epoxy,15S-hydroxy-thromboxa-5Z,13E-dien-1-oic acid

General information

  • TXA2 retards the clearance of aggregated protein in nephritic glomeruli and contributes to the pathophysiology of glomerulonephritis. [1]
  • TXA2 contributes to renal injuries in OLETF(Otsuka Long-Evans Tokushima Fatty ) rats through mechanisms other than hemodynamic injury. [2]
  • Stimulator of platelet aggregation.
  • THA2 contributes to the increased noradrenaline response in mesenteric microvessels perfused in vitro. [3]
  • TXA2 mediates lipopolysaccharide induced rise in pulmonary arterial pressure. [4]
  • TXA2 is the predominant eicosanoid present in all life stages of Trypanosoma cruzi, and Chagas' disease is caused by infection with the parasite T.cruzi. [5]
  • TXA2 exerts a weak inhibitory effect on ulcer healing in rats. [6]
  • TXA2 plays a role in overproduction of lactate during endotoxaemia in NO-deficient rats. [7]
  • TXA2 is a potent constrictor of airway smooth muscle, an inducer of acetylcholine release and of airway microvascular leakage. [8]
  • TXA2 plays an important role in microcirculation disorders in the rat inner ear. [9]
  • TXA2 releases into the portal circulation,contributes to the increased portal resistance in bile duct ligation-induced liver injury. [10]
  • TXA2 plays a significant role in mechanical hyperalgesia induced by autologous nucleus pulposus. [11]
  • TXA2 contributes to the pulmonary circulatory abnormalities in cirrhosis. [12]
  • TXA2 plays a role in the course of acute necrotizing pancreatitis. [13]

Classification

Hormone function

  • homeostasis
    • cardiovascular control

    Chemical classification

    • hormone
      • not genome-encoded
        • eicosanoids/fatty acid derivatives
          • prostanoids
            • thromboxanes

      Composition

      Links to other resources

      LIPID MAPS LMFA03030001
      LipidBank XPR2001

      • Anatomical structure: platelet

      • Anatomical structure: macrophage

      Targets

      CellTP-1TXA2-R
      No records found.
      Reference