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Details for messenger / hormone: PGI2

EndoNet ID: ENH00346

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Synonyms

  • prostaglandin I2
  • PGI2
  • prostacyclin
  • 6,9S-epoxy-11R,15S-dihydoxy-5Z,13E-prostadienoic acid

General information

  • PGI2 plays a role in the course of acute necrotizing pancreatitis. [1]
  • PGI2 plays an important role in regulation of mucosal blood flow. [2]
  • PGI2 increases as a homeostatic reaction to the elevation of blood pressure induced by salt loading. [3]
  • PGI 2, a major metabolite of arachidonic acid in human adipose tissue, is a potent and specific autocrine stimulator of adipogenic differentiation. [4]
  • PGI2 release by adipocytes is stimulated by Ang II. [4]
  • Inhibitor of platelet aggregation.
  • PGI2 protectes the pulmonary vasculature after acute and chronic cigarette smoke exposure. [5]
  • PGI2 plays an important role in cardioprotection,which is mediated by prostacyclin inhibition of platelet aggregation. [6]
  • PGI2 contributes to renal protection against endotoxemia-related acute kidney injury. [7]
  • PGI2 plays a critical role in reduction of motor disturbances through inhibition of tumor necrosis factor production. [8]
  • PGI2 damages the gastric mucosa by expanding vessels and other mechanisms in portal hypertension. [9]
  • PGI2 regulates the endothelium-dependent relaxation, which is induced by acetylcholine in the renal vascular bed of streptozotocin induced diabetic rats. [10]

Classification

Hormone function

  • homeostasis
  • immune response
    • activation

    Chemical classification

    • hormone
      • not genome-encoded
        • eicosanoids/fatty acid derivatives
          • prostanoids
            • prostacyclins

      Composition

      Links to other resources

      KEGG C01312
      LIPID MAPS LMFA03010087
      LipidBank XPR1801

      • Anatomical structure: bone_marrow

      • Anatomical structure: fat_cell

      • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

      • Anatomical structure: osteoblast

        Influenced by:

        • bradykinin receptor B2
          in osteoblast
          • The B2 receptors are linked to a burst of prostanoid release. [11]
        • bradykinin receptor B1
          in osteoblast

      Targets

      CellPGI receptor
      lung Present
      monocyte Present
      pancreas Present
      placenta Present
      platelet Present
      Reference