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Details for messenger / hormone: MIP-1 alpha

EndoNet ID: ENH00348

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Synonyms

  • CCL3
  • LD78-alpha(4-69)
  • small-inducible cytokine A3
  • C-C motif chemokine 3
  • MIP-1 alpha
  • SCYA3
  • MIP1A
  • MIP1-alpha
  • MIP1 alpha
  • chemokine, CC motif, ligand 3
  • small inducible cytokine A3
  • macrophage inflammatory protein 1-alpha
  • macrophage inflammatory protein 1 alpha
  • LD78-alpha
  • tonsillar lymphocyte LD78 alpha protein
  • G0/G1 switch regulatory protein 19-1
  • G0S19-1 protein
  • SIS-beta
  • PAT 464.1
  • pAT464
  • SISalpha
  • TY-5

General information

  • CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins. [1]
  • MIP-1alpha as a costimulatory signal for mast cell-mediated immediate hypersensitivity reactions. [2]
  • The chemokines RANTES, MIP-1 alpha, and MIP-1 beta were identified as the major HIV-suppressive factors produced by CD8+ T cells. [3]
  • MIP-1 alpha is an important mediator of virus-induced inflammation in vivo. [4]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      Small inducible cytokine A3

      Sequence
      SLAADTPTA CCFSYTSRQ IPQNFIADY 
      FETSSQCSK PGVIFLTKR SRQVCADPS 
      EEWVQKYVS DLELSA

      MIP-1-alpha(4-69)

      Sequence
      ADTPTACCF SYTSRQIPQ NFIADYFET 
      SSQCSKPGV IFLTKRSRQ VCADPSEEW 
      VQKYVSDLE LSA

      Links to other resources

      UniProt P10147
      Ensembl ENST00000225245
      KEGG hsa:6348
      • Anatomical structure: lymphocyte

      • Anatomical structure: leukocyte

      • Anatomical structure: T-lymphocyte

      Targets

      CellCCR1CCR5D6
      lipocyte of liver Present
      Phenotypes
      • hepatic stellate cell migration
      • ERK activation
      • positive regulation of cell proliferation
      Influences
      • RANTES
      lung Present
      lymph node Present
      monocyte Present
      Present
      Reference