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Details for messenger / hormone: MIP-1 beta

EndoNet ID: ENH00349

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Synonyms

  • G-26 T-lymphocyte-secreted protein
  • protein H400
  • small-inducible cytokine A4
  • C-C motif chemokine 4
  • MIP-1 beta
  • chemokine, CC motif, ligand 4
  • CCL4
  • SCYA4
  • small inducible cytokine A4
  • macrophage inflammatory protein 1-beta
  • macrophage inflammatory protein 1 beta
  • MIP1B
  • MIP1 beta
  • MIP1B1
  • immune activation 2
  • ACT2
  • AT744.1
  • MIP-1-beta
  • MIP-1-beta(1-69)
  • T-cell activation protein 2
  • PAT 744
  • H400
  • SIS-gamma
  • lymphocyte activation gene 1 protein
  • LAG-1
  • HC21
  • G-26 T lymphocyte-secreted protein

General information

  • The human MIP-1beta chemokine is encoded by two paralogous genes, ACT-2 and LAG-1. [1]
  • Belongs to the CC chemokine subfamily and directs the migration of specific subsets of leukocytes. [1]
  • The chemokines RANTES, MIP-1 alpha, and MIP-1 beta were identified as the major HIV-suppressive factors produced by CD8+ T cells. [2]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      Small inducible cytokine A4

      Sequence 
      APMGSDPPT ACCFSYTAR KLPRNFVVD 
YYETSSLCS QPAVVFQTK RSKQVCADP 
SESWVQEYV YDLELN

      MIP-1-beta(3-69)

      Sequence 
      MGSDPPTAC CFSYTARKL PRNFVVDYY 
ETSSLCSQP AVVFQTKRS KQVCADPSE 
SWVQEYVYD LELN

      Links to other resources

      UniProt P13236
      Ensembl ENST00000250151
      KEGG hsa:9560

      • Anatomical structure: lymphocyte

      • Anatomical structure: monocyte

      • Anatomical structure: B-lymphocyte

      • Anatomical structure: T-lymphocyte

        • Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize MIP-1 beta. [3]

      • Anatomical structure: suppressor_T_cell

        • Perforin-low memory CD8+ cells are the predominant T cells in normal humans that synthesize MIP-1 beta. [3]

      Targets

      CellCCR1CCR5
      lipocyte of liver Present
      Phenotypes
      • hepatic stellate cell migration
      • ERK activation
      • positive regulation of cell proliferation
      Influences
      • ↑ RANTES
      monocyte Present
      		Present
      Reference