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Details for messenger / hormone: MIP-3 beta

EndoNet ID: ENH00350

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Synonyms

  • Epstein-Barr virus-induced molecule 1 ligand chemokine
  • small-inducible cytokine A19
  • C-C motif chemokine 19
  • MIP-3 beta
  • CCL19
  • MIP3 beta
  • small inducible cytokine A19
  • MIP-3-beta
  • EBI1-ligand chemokine
  • ELC
  • beta chemokine exodus-3
  • CK beta-11
  • SCYA19
  • MIP3B
  • chemokine, CC motif, ligand 19
  • macrophage inflammatory protein 3-beta
  • macrophage inflammatory protein 3 beta
  • exodus 3

General information

  • MIP-3 beta / CCL19 acts directly on human monocytes and T cells. [1]
  • The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. [2]
  • CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells. [3]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      Sequence
      GTNDAEDCC LSVTQKPIP GYIVRNFHY 
      LLIKDGCRV PAVVFTTLR GRQLCAPPD 
      QPWVERIIQ RLQRTSAKM KRRSS

      Links to other resources

      UniProt Q99731
      Ensembl ENST00000311925
      KEGG hsa:6363
      • Anatomical structure: thymus

      • Anatomical structure: colon

      • Anatomical structure: spleen

      • Anatomical structure: small_intestine

      • Anatomical structure: lung

      • Anatomical structure: kidney

      • Anatomical structure: stomach

      • Anatomical structure: dendritic_cell_in_lymphoid_tissues

      Targets

      CellCCR11CCR7
      B-lymphocyte Present
      dendritic cell in lymphoid tissues Present
      Phenotypes
      • dendritic cell chemotaxis
      lymphoid tissue Present
      T-lymphocyte Present
      Reference