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Details for messenger / hormone: IL-17A

EndoNet ID: ENH00354

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Synonyms

  • IL-17A
  • cytotoxic T-lymphocyte-associated antigen 8
  • Interleukin-17A
  • IL17A
  • interleukin 17A
  • IL 17A
  • cytotoxic T lymphocyte-associated antigen 8
  • IL-17
  • CTLA-8
  • cytotoxic T-lymphocyte-associated serine esterase 8

General information

  • IL-17 and IL-15 stimulate osteoclastogenesis and bone resorptiion. [1]
  • IL-17 is a pro-inflammatory cytokine that is primarily secreted from T lymphocytes, mediators of adaptive immunity. [2]
  • IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. [3]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • IL-17 family

      Composition

      Homodimer (2 times)

      Sequence
      GITIPRNPG CPNSEDKNF PRTVMVNLN 
      IHNRNTNTN PKRSSDYYN RSTSPWNLH 
      RNEDPERYP SVIWEAKCR HLGCINADG 
      NVDYHMNSV PIQQEILVL RREPPHCPN 
      SFRLEKILV SVGCTCVTP IVHHVA

      Links to other resources

      UniProt Q16552
      Ensembl ENST00000340057
      KEGG hsa:3605
      • Anatomical structure: T-lymphocyte

      Targets

      CellIL-17R
      bronchi Present
      Influences
      • IL-8
      • GROalpha
      Reference