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Details for messenger / hormone: CD40-L

EndoNet ID: ENH00357

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Synonyms

  • CD154
  • T-cell antigen Gp39
  • tumor necrosis factor ligand superfamily member 5
  • CD40-L
  • TRAP
  • TNFSF5
  • gp39
  • CD40LG
  • CD40L
  • T-BAM
  • sCD40L
  • CD40 ligand
  • TNF-related activation protein
  • soluble CD40 ligand

General information

  • Interaction of CD40L and its cognate receptor is an essential component of B-lymphocyte signaling, affecting various aspects of B-cell differentiation pathways and immunoglobulin gene expression. [1]
  • CD40 ligand gene defects are responsible for X-linked hyper-IgM syndrome. [2]
  • TNF-alpha blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation. [3]
  • CD40L generates immune responses in leukemia-bearing mice, an effect that is potentiated by IL-2. [4]
  • CD40L induces the production by proximal tubular epithelial cells of different proinflammatory cytokines. [5]
  • CD40 ligand is expressed on platelets and released from them on activation. [6]
  • Elevation of soluble CD40 ligand levels indicates an increased risk of cardiovascular events. [6]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TNF family

      Composition

      membrane form

      Sequence 
      MIETYNQTS PRSAATGLP ISMKIFMYL 
LTVFLITQM IGSALFAVY LHRRLDKIE 
DERNLHEDF VFMKTIQRC NTGERSLSL 
LNCEEIKSQ FEGFVKDIM LNKEETKKE 
NSFEMQKGD QNPQIAAHV ISEASSKTT 
SVLQWAEKG YYTMSNNLV TLENGKQLT 
VKRQGLYYI YAQVTFCSN REASSQAPF 
IASLCLKSP GRFERILLR AANTHSSAK 
PCGQQSIHL GGVFELQPG ASVFVNVTD 
PSQVSHGTG FTSFGLLKL

      Links to other resources

      UniProt P29965
      Ensembl ENST00000370629
      KEGG hsa:959

      • Anatomical structure: osteoclast

      • Anatomical structure: macrophage

      • Anatomical structure: platelet

      Targets

      CellCD40SHPS-1-1
      cell of endometrium of uterus Present
      lipocyte of liver Present
      Influences
      • ↑ RANTES
      muscularis of uterus Present
      platelet Present
      sinusoidal endothelial cell Present
      Reference