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Details for messenger / hormone: BMP2

EndoNet ID: ENH00366

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Synonyms

  • bone morphogenetic protein 2A
  • BMP2
  • BMP-2
  • BMP-2A
  • bone morphogenetic protein 2

General information

  • BMP2 induced Wnt1 and Wnt3a expression in C3H10T1/2 cells and thus may play a role in initiating autocrine Wnt signaling. [1]
  • GREMLIN and DANTE are secreted antagonists for BMPs and SLITs. [2]
  • BMP-2 is a negative growth regulator in the retina and retinal pigmented epithelium that are downregulated by injury. [3]
  • Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine. [4]
  • Induces cartilage and bone formation. [4]
  • BMP-2 induces apoptosis by protein kinase C-dependent, Smad 1-independent mechanisms. [5]

Classification

Hormone function

  • development and growth
    • growth stimulation
      • apoptosis

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • TGF-beta family

        Composition

        Sequence 
        QAKHKQRKR LKSSCKRHP LYVDFSDVG 
WNDWIVAPP GYHAFYCHG ECPFPLADH 
LNSTNHAIV QTLVNSVNS KIPKACCVP 
TELSAISML YLDENEKVV LKNYQDMVV 
EGCGCR

        Links to other resources

        UniProt P12643
        Ensembl ENST00000378827
        KEGG hsa:650

        • Anatomical structure: lung

        • Anatomical structure: spleen

        • Anatomical structure: colon

        • Anatomical structure: heart

        • Anatomical structure: brain

        • Anatomical structure: placenta

        • Anatomical structure: skeleton_muscle

        • Anatomical structure: pancreas

        • Anatomical structure: prostate

        • Anatomical structure: small_intestine

        • Anatomical structure: ovary

        • Anatomical structure: substantia_propria_of_cornea

          • Transcription of BMP-2, BMP-3, BMP-4, BMP-5, and BMP-7 and receptors of BMPR-IA, BMPR-IB and BMPR-II was detected in ex vivo and cultured corneal epithelium and stroma. [6]

        • Anatomical structure: corneal_endothelial_cell

          • Transcription of BMP-2, BMP-3, BMP-4, BMP-5, and BMP-7 and receptors of BMPR-IA, BMPR-IB and BMPR-II was detected in ex vivo and cultured epithelium and stroma. [6]

        Targets

        CellBMP receptor type 1ABMP receptor type II
        adrenal cortex Present
        Phenotypes
        • Familial juvenile polyposis
        		Present
        Phenotypes
        • negative regulation of steroid hormone biosynthetic
        • regulation of steroid biosynthetic process
        • negative regulation of adrenocorticotropin receptor activity
        Influences
        • ↑ aldosterone
        • ↓ aldosterone
        • ↓ cortisol
        adrenal medulla Present
        Phenotypes
        • regulation of cell fate specification
        • negative regulation of catecholamine biosynthetic process
        fibroblast Present
        heart Present
        hepatocyte Present
        skeleton muscle Present
        skin Present
        Reference