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Details for messenger / hormone: BMP4

EndoNet ID: ENH00367

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Synonyms

  • BMP-4
  • bone morphogenetic protein 2B
  • BMP4
  • BMP-2B
  • BMP2B
  • bone morphogenetic protein 4
  • DVR4

General information

  • GREMLIN and DANTE are secreted antagonists for BMPs and SLITs. [1]
  • The activation of BMP4 mediates the changes in morphology, adhesion, motility and invasion in human ovarian cancer cells. [2]
  • BMP-4 is a negative growth regulator in the retina and retinal pigmented epithelium that are downregulated by injury. [3]
  • Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines. [4]
  • Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. [4]
  • BMP-4 has an inhibitory role on corticotroph tumorigenesis in vivo. [5]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      Sequence 
      SPKHHSQRA RKKNKNCRR HSLYVDFSD 
VGWNDWIVA PPGYQAFYC HGDCPFPLA 
DHLNSTNHA IVQTLVNSV NSSIPKACC 
VPTELSAIS MLYLDEYDK VVLKNYQEM 
VVEGCGCR

      Links to other resources

      UniProt P12644
      Ensembl ENST00000417573
      KEGG hsa:652

      • Anatomical structure: lung

      • Anatomical structure: prostate

      • Anatomical structure: kidney

      • Anatomical structure: corneal_endothelial_cell

      • Anatomical structure: theca_cell

      • Anatomical structure: adrenal_cortex

      Targets

      CellBMP receptor type 1ABMP receptor type II
      adrenal cortex Present
      Phenotypes
      • Familial juvenile polyposis
      		Present
      Phenotypes
      • negative regulation of steroid hormone biosynthetic
      • regulation of steroid biosynthetic process
      • negative regulation of adrenocorticotropin receptor activity
      Influences
      • ↑ aldosterone
      • ↓ aldosterone
      • ↓ cortisol
      adrenal medulla Present
      Phenotypes
      • regulation of cell fate specification
      • negative regulation of catecholamine biosynthetic process
      fibroblast Present
      heart Present
      hepatocyte Present
      skeleton muscle Present
      skin Present
      Reference