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Details for messenger / hormone: BMP6

EndoNet ID: ENH00368

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Synonyms

  • BMP-6
  • bone morphogenetic protein 6
  • Vgr-1
  • BMP6
  • vg-1-related protein
  • Vgr1

General information

  • GREMLIN and DANTE are secreted antagonists for BMPs and SLITs. [1]
  • Induces cartilage and bone formation. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      Sequence 
      QQSRNRSTQ SQDVARVSS ASDYNSSEL 
KTACRKHEL YVSFQDLGW QDWIIAPKG 
YAANYCDGE CSFPLNAHM NATNHAIVQ 
TLVHLMNPE YVPKPCCAP TKLNAISVL 
YFDDNSNVI LKKYRNMVV RACGCH

      Links to other resources

      UniProt P22004
      Ensembl ENST00000283147
      KEGG hsa:654

      • Anatomical structure: theca_cell

      Targets

      Cellactivin receptor type 2Bactivin receptor type IBMP receptor type II
      adrenal cortex Present
      Phenotypes
      • negative regulation of steroid hormone biosynthetic
      • regulation of steroid biosynthetic process
      • negative regulation of adrenocorticotropin receptor activity
      Influences
      • ↑ aldosterone
      • ↓ aldosterone
      • ↓ cortisol
      adrenal medulla Present
      Phenotypes
      • regulation of cell fate specification
      • negative regulation of catecholamine biosynthetic process
      cell of endometrium of uterus Present
      Phenotypes
      • cell differentiation
      chondrocyte Present
      Phenotypes
      • fibrodysplasia ossificans progressiva (FOP)
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      fibroblast Present
      		Present
      heart Present
      hepatocyte Present
      muscle Present
      pancreas Present
      pancreatic islets Present
      Phenotypes
      • embryonic digestive tract development
      skin Present
      Reference