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Details for messenger / hormone: BMP7

EndoNet ID: ENH00369

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Synonyms

  • BMP7
  • osteogenic protein 1
  • BMP-7
  • bone morphogenetic protein 7
  • OP-1
  • OP1
  • osteogenetic protein 1
  • eptotermin alfa

General information

  • BMP7 is a novel therapeutic molecule for treatment of metastatic bone disease. [1]
  • Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. [2]
  • BMP7 plays an important role in the regulation of anti-inflammatory response in the adult gut tissue. [3]
  • Recombinant human BMP7(cross talk between BMP-7 and transforming growth factor-beta1) leads to repair of severely damaged renal tubular epithelial cells, in association with reversal of chronic renal injury. [4]
  • BMP-7 inhibits constitutive and interleukin-1 beta-induced monocyte chemoattractant protein-1 expression in human mesangial cells. [5]
  • BMP7 restores skeletal anabolic balance in animal models of CKD with disordered skeletal modeling. [6]
  • Bone morphogenetic protein 7 inhibits tubular epithelial cell de-differentiation, mesenchymal transformation and apoptosis stimulated by various renal injuries. It also preserves glomerular integrity and inhibits injury-mediated mesangial matrix accumulation. [7]
  • BMP7 was shown to prevent vascular calcification in a model of chronic kidney disease associated with the restoration of osteocalcin expression to normal tissue-restricted sites. [7]
  • Forms heterodimers with Nodal proteins, resulting in mutual inhibition. [8]
  • Expressed in the kidneys and bladder. Lower levels seen in the brain. [2]
  • GREMLIN and DANTE are secreted antagonists for BMPs and SLITs. [9]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      Sequence 
      STGSKQRSQ NRSKTPKNQ EALRMANVA 
ENSSSDQRQ ACKKHELYV SFRDLGWQD 
WIIAPEGYA AYYCEGECA FPLNSYMNA 
TNHAIVQTL VHFINPETV PKPCCAPTQ 
LNAISVLYF DDSSNVILK KYRNMVVRA 
CGCH

      Links to other resources

      UniProt P18075
      Ensembl ENST00000395863
      KEGG hsa:655

      • Anatomical structure: kidney

      • Anatomical structure: brain

      • Anatomical structure: urinary_bladder

      • Anatomical structure: substantia_propria_of_cornea

      • Anatomical structure: corneal_endothelial_cell

      • Anatomical structure: theca_cell

      Targets

      CellBMP receptor type II
      adrenal cortex Present
      Phenotypes
      • negative regulation of steroid hormone biosynthetic
      • regulation of steroid biosynthetic process
      • negative regulation of adrenocorticotropin receptor activity
      Influences
      • ↑ aldosterone
      • ↓ aldosterone
      • ↓ cortisol
      adrenal medulla Present
      Phenotypes
      • regulation of cell fate specification
      • negative regulation of catecholamine biosynthetic process
      fibroblast Present
      heart Present
      hepatocyte Present
      skin Present
      Reference