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Details for messenger / hormone: GDF5

EndoNet ID: ENH00371

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Synonyms

  • CDMP1
  • Radotermin
  • growth/differentiation factor 5
  • CDMP-1
  • cartilage-derived morphogenetic protein 1
  • GDF-5
  • BMP-14
  • BMP14
  • GDF5
  • growth/differentiation factor 5.

General information

  • Predominantly expressed in long bones during human embryonic development. [1]
  • GREMLIN and DANTE are secreted antagonists for BMPs and SLITs. [2]
  • The absence of BMP-14 causes the delay in cellular recruitment and chondrocyte differentiation in the early stages fracture repair. [3]
  • Involved in the embryonic skeletal development.

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      Sequence 
      APLATRQGK RPSKNLKAR CSRKALHVN 
FKDMGWDDW IIAPLEYEA FHCEGLCEF 
PLRSHLEPT NHAVIQTLM NSMDPESTP 
PTCCVPTRL SPISILFID SANNVVYKQ 
YEDMVVESC GCR

      Links to other resources

      UniProt P43026
      Ensembl ENST00000374372
      KEGG hsa:8200

      • Anatomical structure: substantia_propria_of_cornea

        • GDF-5 was transcribed only in corneal stromal cells (not in corneal epithelium), suggesting that this cytokine may be an important mediator between keratocytes and epithelial cells. [4]
        • GDF-5 inhibited proliferation of corneal epithelial and stromal cells. [4]

      • Anatomical structure: articular_cartilage

      Targets

      CellBMP receptor type IB
      adrenal medulla Present
      Phenotypes
      • positive regulation of adrenal development
      chondrocyte Present
      Phenotypes
      • brachydactyly type A2
      • acromesomelic chondrodysplasia with genital anomalies
      granulosa cell Present
      Influences
      • ↓ progesterone
      • ↑ estradiol
      Reference