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Details for messenger / hormone: GDF-6

EndoNet ID: ENH00373

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Synonyms

  • growth/differentiation factor 16
  • GDF-6
  • GDF6
  • growth/differentiation factor 6
  • BMP-13
  • BMP13
  • CDMP-2
  • cartilage-derived morphogenic protein-2
  • CDMP2

General information

  • Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Play a key role in establishing boundaries between skeletal elements during development. [1]
  • GREMLIN and DANTE are secreted antagonists for BMPs and SLITs. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      Sequence
      FQQASISSS SSSAELGST KGMRSRKEG 
      KMQRAPRDS DAGREGQEP QPRPQDEPR 
      AQQPRAQEP PGRGPRVVP HEYMLSIYR 
      TYSIAEKLG INASFFQSS KSANTITSF 
      VDRGLDDLS HTPLRRQKY LFDVSMLSD 
      KEELVGAEL RLFRQAPSA PWGPPAGPL 
      HVQLFPCLS PLLLDARTL DPQGAPPAG 
      WEVFDVWQG LRHQPWKQL CLELRAAWG 
      ELDAGEAEA RARGPQQPP PPDLRSLGF 
      GRRVRPPQE RALLVVFTR SQRKNLFAE 
      MREQLGSAE AAGPGAGAE GSWPPPSGA 
      PDARPWLPS PGRRRRRTA FASRHGKRH 
      GKKSRLRCS KKPLHVNFK ELGWDDWII 
      APLEYEAYH CEGVCDFPL RSHLEPTNH 
      AIIQTLMNS MDPGSTPPS CCVPTKLTP 
      ISILYIDAG NNVVYKQYE DMVVESCGC 
      R

      Links to other resources

      UniProt Q6KF10
      Ensembl ENST00000287020
      KEGG hsa:392255
      • Anatomical structure: chondrocyte

      • Anatomical structure: articular_cartilage

      Targets

      CellBMP receptor type 1ABMP receptor type II
      adrenal cortex Present
      Phenotypes
      • Familial juvenile polyposis
      Present
      Phenotypes
      • negative regulation of steroid hormone biosynthetic
      • regulation of steroid biosynthetic process
      • negative regulation of adrenocorticotropin receptor activity
      Influences
      • aldosterone
      • aldosterone
      • cortisol
      adrenal medulla Present
      Phenotypes
      • regulation of cell fate specification
      • negative regulation of catecholamine biosynthetic process
      fibroblast Present
      heart Present
      hepatocyte Present
      skeleton muscle Present
      skin Present
      Reference