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Details for messenger / hormone: AMH

EndoNet ID: ENH00374

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Synonyms

  • Muellerian-inhibiting substance
  • AMH
  • anti-Muellerian hormone
  • MIS
  • muellerian-inhibiting factor
  • muellerian inhibiting substance

General information

  • Causes regression of the Muellerian duct, inhibits the growth of tumors derived from tissues of Muellerian origin.
  • AMH signals through 2 transmembrane receptors, type II which is specific and type I receptors, shared with the bone morphogenetic protein family. Mutations of the AMH and AMH receptor type II (AMHR-II) genes lead to persistence of the uterus and Fallopian tubes in males. [1]
  • Anti-Mullerian hormone is a dimeric glycoprotein, member of the TGF superfamily, produced exclusively in the gonads and involved in the regulation of follicular growth and development. [2]
  • Mullerian inhibiting substance acts as a motor neuron survival factor in vitro. [3]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      Sequence 
      RAEEPAVGT SGLIFREDL DWPPGIPQE 
PLCLVALGG DSNGSSSPL RVVGALSAY 
EQAFLGAVQ RARWGPRDL ATFGVCNTG 
DRQAALPSL RRLGAWLRD PGGQRLVVL 
HLEEVTWEP TPSLRFQEP PPGGAGPPE 
LALLVLYPG PGPEVTVTR AGLPGAQSL 
CPSRDTRYL VLAVDRPAG AWRGSGLAL 
TLQPRGEDS RLSTARLQA LLFGDDHRC 
FTRMTPALL LLPRSEPAP LPAHGQLDT 
VPFPPPRPS AELEESPPS ADPFLETLT 
RLVRALRVP PARASAPRL ALDPDALAG 
FPQGLVNLS DPAALERLL DGEEPLLLL 
LRPTAATTG DPAPLHDPT SAPWATALA 
RRVAAELQA AAAELRSLP GLPPATAPL 
LARLLALCP GGPGGLGDP LRALLLLKA 
LQGLRVEWR GRDPRGPGR AQRSAGATA 
ADGPCALRE LSVDLRAER SVLIPETYQ 
ANNCQGVCG WPQSDRNPR YGNHVVLLL 
KMQARGAAL ARPPCCVPT AYAGKLLIS 
LSEERISAH HVPNMVATE CGCR

      anti-Mullerian hormone

      Sequence 
      RAEEPAVGT SGLIFREDL DWPPGIPQE 
PLCLVALGG DSNGSSSPL RVVGALSAY 
EQAFLGAVQ RARWGPRDL ATFGVCNTG 
DRQAALPSL RRLGAWLRD PGGQRLVVL 
HLEEVTWEP TPSLRFQEP PPGGAGPPE 
LALLVLYPG PGPEVTVTR AGLPGAQSL 
CPSRDTRYL VLAVDRPAG AWRGSGLAL 
TLQPRGEDS RLSTARLQA LLFGDDHRC 
FTRMTPALL LLPRSEPAP LPAHGQLDT 
VPFPPPRPS AELEESPPS ADPFLETLT 
RLVRALRVP PARASAPRL ALDPDALAG 
FPQGLVNLS DPAALERLL DGEEPLLLL 
LRPTAATTG DPAPLHDPT SAPWATALA 
RRVAAELQA AAAELRSLP GLPPATAPL 
LARLLALCP GGPGGLGDP LRALLLLKA 
LQGLRVEWR GRDPRGPGR AQRSAGATA 
ADGPCALRE LSVDLRAER SVLIPETYQ 
ANNCQGVCG WPQSDRNPR YGNHVVLLL 
KMQARGAAL ARPPCCVPT AYAGKLLIS 
LSEERISAH HVPNMVATE CGCR

      Links to other resources

      UniProt P03971
      Ensembl ENST00000221496

      • Anatomical structure: Sertoli_cell

        • This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin. [4]

      Targets

      Cellactivin receptor type IAMHR-II
      chondrocyte Present
      Phenotypes
      • fibrodysplasia ossificans progressiva (FOP)
      continuous vascular endothelial cell of blood vessels and lymphatics Present
      fibroblast Present
      muscle Present
      pancreas Present
      Reference