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Details for messenger / hormone: GDNF

EndoNet ID: ENH00376

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Synonyms

  • astrocyte-derived trophic factor
  • glial cell line-derived neurotrophic factor
  • GDNF
  • glial cell-line-derived neurotrophic factor
  • glial cell derived neurotrophic factor
  • ATF-1
  • astrocyte-derived trophic factor 1
  • ATF

General information

  • Promotes dopamine uptake and survival and morphological differentiation of midbrain neurons.
  • Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      Sequence
      SPDKQMAVL PRRERNRQA AAANPENSR 
      GKGRRGQRG KNRGCVLTA IHLNVTDLG 
      LGYETKEEL IFRYCSGSC DAAETTYDK 
      ILKNLSRNR RLVSDKVGQ ACCRPIAFD 
      DDLSFLDDN LVYHILRKH SAKRCGCI

      Links to other resources

      UniProt P39905
      Ensembl ENST00000427982
      KEGG hsa:2668

        Targets

        CellGFR-alpha-1GFR-alpha-2
        brain Present
        Phenotypes
        • regulates noxious heat transduction
        placenta Present
        Reference