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Details for messenger / hormone: neurturin

EndoNet ID: ENH00377

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Synonyms

  • NTN
  • neurturin
  • NRTN

General information

  • Neurturin (NTN), a potent neurotrophic factor acting specifically on dopaminergic neurons, is comprised of 102 amino acids as a mature protein. [1]
  • GDNF and NRTN are new neuromodulators that regulate the development of the neuromuscular synapse through both pre- and postsynaptic mechanisms. [2]
  • Neurturin has been shown to bind to a high affinity glycosylphosphatidylinositol (GPI)-linked receptor (GFRalpha2) and induce phosphorylation of the tyrosine kinase receptor Ret, resulting in the activation of the MAPK signalling pathway. [3]
  • Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. [4]

Classification

Hormone function

  • development and growth
    • environment adaptation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      Sequence
      ARLGARPCG LRELEVRVS ELGLGYASD 
      ETVLFRYCA GACEAAARV YDLGLRRLR 
      QRRRLRRER VRAQPCCRP TAYEDEVSF 
      LDAHSRYHT VHELSAREC ACV

      Links to other resources

      UniProt Q99748
      Ensembl ENST00000303212
      KEGG hsa:4902

        Targets

        CellGFR-alpha-1GFR-alpha-2
        brain Present
        Phenotypes
        • regulates noxious heat transduction
        placenta Present
        Reference