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Details for messenger / hormone: ART

EndoNet ID: ENH00378

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Synonyms

  • ART
  • artemin
  • ARTN
  • neurotrophic factor artemin
  • enovin
  • neublastin
  • EVN

General information

  • ARTN is a member of the GDNF family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. [1]
  • Required for the survival of sensory and sympathetic neurons in culture, promotes neuronal proliferation.
  • Artemin, a neuronal survival factor in the glial cell line-derived neurotrophic factor family, binds the glycosylphosphatidylinositol-anchored protein GFRalpha3 and the receptor tyrosine kinase Ret. [2]
  • Artemin has potent neurotrophic actions on injured C-fibres. [3]
  • The neurotrophic factor artemin promotes pancreatic cancer invasion. [4]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • TGF-beta family

      Composition

      Sequence 
      AGGPGSRAR AAGARGCRL RSQLVPVRA 
LGLGHRSDE LVRFRFCSG SCRRARSPH 
DLSLASLLG AGALRPPPG SRPVSQPCC 
RPTRYEAVS FMDVNSTWR TVDRLSATA 
CGCLG

      Links to other resources

      UniProt O96030
      Ensembl ENST00000372359
      KEGG hsa:9048

        Targets

        CellGFR-alpha-1GFR-alpha-2GFR-alpha-3
        brain Present
        Phenotypes
        • regulates noxious heat transduction
        placenta Present
        Reference