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Details for messenger / hormone: IL-1RA

EndoNet ID: ENH00382

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Synonyms

  • ICIL-1RA
  • interleukin-1 receptor antagonist protein
  • interleukin 1 receptor antagonist
  • IL-1RA
  • IL1RA
  • IL1RN
  • IRAP
  • IL1 inhibitor
  • interleukin-1 receptor antagonist

General information

  • Inhibits the activity of IL-1 by binding to its receptor. Has no IL-1 like activity. [1]

Classification

Hormone function

  • immune response
    • inhibition

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    isoform 1

    Sequence
    RPSGRKSSK MQAFRIWDV NQKTFYLRN 
    NQLVAGYLQ GPNVNLEEK IDVVPIEPH 
    ALFLGIHGG KMCLSCVKS GDETRLQLE 
    AVNITDLSE NRKQDKRFA FIRSDSGPT 
    TSFESAACP GWFLCTAME ADQPVSLTN 
    MPDEGVMVT KFYFQEDE
    UniProt P18510-1

    Links to other resources

    UniProt P18510
    Ensembl ENST00000409930
    KEGG hsa:3557
    • Anatomical structure: neutrophil_granulocyte

      • In LPS-challenged neutrophils, large amounts of soluble TNFRs p55 and p75 (sTNFRI, sTNFRII), and IL-1R antagonist (IL-1RA), rising constantly with the cell density, were detected. [2]
    • Anatomical structure: hepatocyte

      Influenced by:

      • TNFR1
        in hepatocyte
        • TNF induces the release of IL-1ra. [3]
      • TNFR2
        in hepatocyte
        • TNF induces the release of IL-1ra. [3]

    Targets

    CellIL-1RIIL-1RII
    bronchial epithelial cell Present
    Influences
    • IL-8
    • lipocalin 2
    cell of endometrium of uterus Present
    Influences
    • LIF
    • interleukin 6
    dendritic cell in lymphoid tissues follicular Present
    epithelial cell Present
    epithelial cell with microvilli Present
    Influences
    • IL-8
    lipocyte of liver Present
    Influences
    • RANTES
    Present
    Influences
    • RANTES
    macrophage Present
    Influences
    • PAF
    monocyte Present
    Influences
    • PAF
    osteoblast Present
    osteoclast Present
    Present
    parathyroid gland Present
    Influences
    • PTH
    pneumocyte type II Present
    Influences
    • lipocalin 2
    • IL-8
    Reference