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Details for messenger / hormone: IL-1F5

EndoNet ID: ENH00384

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Synonyms

  • interleukin-1 HY1
  • interleukin-1 family member 5
  • IL-1F5
  • interleukin-1 receptor antagonist homolog 1
  • interleukin-1 delta
  • IL-1 delta
  • FIL1 delta
  • interleukin-1-like protein 1
  • IL1RP3
  • IL-1-related protein 3
  • IL-1ra homolog 1

General information

  • s a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response. [1]
  • Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines

    Composition

    Sequence 
    MVLSGALCF RMKDSALKV LYLHNNQLL 
AGGLHAGKV IKGEEISVV PNRWLDASL 
SPVILGVQG GSQCLSCGV GQEPTLTLE 
PVNIMELYL GAKESKSFT FYRRDMGLT 
SSFESAAYP GWFLCTVPE ADQPVRLTQ 
LPENGGWNA PITDFYFQQ CD

    Links to other resources

    UniProt Q9UBH0
    Ensembl ENST00000393200
    KEGG hsa:26525

    • Anatomical structure: keratinocyte

      • In vitro-cultured keratinocytes contained ~10-fold more IL-1{delta} mRNA relative to IL-1{epsilon} mRNA. [2]

    • Anatomical structure: spleen

    • Anatomical structure: macrophage

    • Anatomical structure: lung

    • Anatomical structure: melanocyte

    • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

    Targets

    Cell
    No records found.
    Reference