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Details for messenger / hormone: BCA-1

EndoNet ID: ENH00390

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Synonyms

  • Angie
  • B cell-attracting chemokine 1
  • CXC chemokine BLC
  • B lymphocyte chemoattractant
  • small-inducible cytokine B13
  • C-X-C motif chemokine 13
  • BCA-1
  • B-cell attracting chemokine 1
  • B-lymphocyte chemoattractant
  • BLC
  • CXCL13
  • SCYB13
  • small inducible cytokine B13

General information

  • Highest levels in liver, followed by spleen, lymph node, appendix and stomach. Low levels in salivary gland, mammary gland and fetal spleen. [1]
  • Chemotactive for B lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B lymphocytes. Binds to BLR1/CXCR5. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CXC chemokines

      Composition

      Sequence 
      VLEVYYTSL RCRCVQESS VFIPRRFID 
RIQILPRGN GCPRKEIIV WKKNKSIVC 
VDPQAEWIQ RMMEVLRKR SSSTLPVPV 
FKRKIP

      Links to other resources

      UniProt O43927
      Ensembl ENST00000286758
      KEGG hsa:10563

      • Anatomical structure: stomach

      • Anatomical structure: spleen

      • Anatomical structure: major_salivary_glands

      • Anatomical structure: mammary_gland

      • Anatomical structure: lymph_node

      • Anatomical structure: appendix

      Targets

      CellCXCR5
      killer cell Present
      Reference