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Details for messenger / hormone: PF-4

EndoNet ID: ENH00391

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Synonyms

  • Oncostatin-A
  • C-X-C motif chemokine 4
  • PF-4
  • PF4
  • platelet factor 4
  • CXCL4
  • oncostatin A
  • iroplact
  • SCYB4

General information

  • Platelet factor 4, noncovalently bound to a proteoglycan molecule, is released during platelet aggregation. PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. [1]
  • Chemotactic for neutrophils and monocytes. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CXC chemokines

      Composition

      Sequence
      EAEEDGDLQ CLCVKTTSQ VRPRHITSL 
      EVIKAGPHC PTAQLIATL KNGRKICLD 
      LQAPLYKKI IKKLLES

      Links to other resources

      UniProt P02776
      Ensembl ENST00000296029
      KEGG hsa:5196
      • Anatomical structure: platelet

        • Released during platelet aggregation. [1]

      Targets

      CellCXCR3
      killer cell Present
      monocyte Present
      Reference