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Details for messenger / hormone: MIP-3 alpha

EndoNet ID: ENH00394

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Synonyms

  • small-inducible cytokine A20
  • C-C motif chemokine 20
  • MIP-3 alpha
  • MIP-3-alpha
  • macrophage inflammatory protein 3 alpha
  • liver and activation-regulated chemokine
  • CC chemokine LARC
  • beta chemokine exodus-1

General information

  • Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. [1]
  • C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli ATCC 25922 and S.aureus ATCC. [1]
  • Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon. [1]
  • Induction: By lipopolysaccharide (LPS), tumor necrosis factor and interferon gamma. Induced by phorbol myristate acetate (PMA) in U937 cell line and bowes melanoma. Repressed by IL-10. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      small inducible cytokine A20

      Sequence 
      ASNFDCCLG YTDRILHPK FIVGFTRQL 
ANEGCDINA IIFHTKKKL SVCANPKQT 
WVKYIVRLL SKKVKNM

      Links to other resources

      UniProt P78556
      Ensembl ENST00000358813
      KEGG hsa:6364

      • Anatomical structure: lymph_node

      • Anatomical structure: appendix

      • Anatomical structure: prostate

      • Anatomical structure: testis

      • Anatomical structure: small_intestine

      • Anatomical structure: thymus

      • Anatomical structure: colon

      Targets

      CellCCR6
      B-lymphocyte Present
      Phenotypes
      • chemotaxis of lymphocytes
      dendritic cell in lymphoid tissues Present
      Phenotypes
      • dendritic cell chemotaxis
      memory cell T Present
      Phenotypes
      • chemotaxis of lymphocytes
      neutrophil granulocyte Present
      Phenotypes
      • Neutrophil chemotaxis
      Reference