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Details for messenger / hormone: eotaxin

EndoNet ID: ENH00395

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Synonyms

  • small-inducible cytokine A11
  • C-C motif chemokine 11
  • Eot
  • CCL11
  • eosinophil chemotactic protein
  • eotaxin
  • SCYA11
  • small inducible cytokine A11

General information

  • In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. [1]
  • Eotaxin, a CC chemokine, is important in extrinsic asthma, an inflammatory disorder. [2]
  • Circulating eotaxin and eotaxin mRNA levels in visceral adipose tissue were increased in obesity in mice and humans. [2]
  • Human eotaxin is an 8,3-kDa, 74-amino-acid residue, nonglycosylated polypeptide secreted by endothelial cells, fibroblasts, macrophages, ciliated and nonciliated bronchial epithelial cells, smooth muscle cells, chondrocytes, and eosinophils. [2]
  • Induction: By TNF-alpha, interleukin-1 alpha and interferon gamma. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      eotaxin

      Sequence 
      GPASVPTTC CFNLANRKI PLQRLESYR 
RITSGKCPQ KAVIFKTKL AKDICADPK 
KKWVQDSMK YLDQKSPTP KP

      Links to other resources

      UniProt P51671
      Ensembl ENST00000305869
      KEGG hsa:6356

      • Anatomical structure: continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics

        • Human eotaxin is an 8,3-kDa, 74-amino-acid residue, nonglycosylated polypeptide secreted by endothelial cells, fibroblasts, macrophages, ciliated and nonciliated bronchial epithelial cells, smooth muscle cells, chondrocytes, and eosinophils. [2]

      • Anatomical structure: fibroblast

        • Human eotaxin is an 8,3-kDa, 74-amino-acid residue, nonglycosylated polypeptide secreted by endothelial cells, fibroblasts, macrophages, ciliated and nonciliated bronchial epithelial cells, smooth muscle cells, chondrocytes, and eosinophils. [2]

      • Anatomical structure: macrophage

        • Human eotaxin is an 8,3-kDa, 74-amino-acid residue, nonglycosylated polypeptide secreted by endothelial cells, fibroblasts, macrophages, ciliated and nonciliated bronchial epithelial cells, smooth muscle cells, chondrocytes, and eosinophils. [2]

      • Anatomical structure: lung

        • Human eotaxin is an 8,3-kDa, 74-amino-acid residue, nonglycosylated polypeptide secreted by endothelial cells, fibroblasts, macrophages, ciliated and nonciliated bronchial epithelial cells, smooth muscle cells, chondrocytes, and eosinophils. [2]

      • Anatomical structure: smooth_muscle

        • Human eotaxin is an 8,3-kDa, 74-amino-acid residue, nonglycosylated polypeptide secreted by endothelial cells, fibroblasts, macrophages, ciliated and nonciliated bronchial epithelial cells, smooth muscle cells, chondrocytes, and eosinophils. [2]

      • Anatomical structure: chondrocyte

        • Human eotaxin is an 8,3-kDa, 74-amino-acid residue, nonglycosylated polypeptide secreted by endothelial cells, fibroblasts, macrophages, ciliated and nonciliated bronchial epithelial cells, smooth muscle cells, chondrocytes, and eosinophils. [2]

      • Anatomical structure: eosinophil_granulocyte

        • Human eotaxin is an 8,3-kDa, 74-amino-acid residue, nonglycosylated polypeptide secreted by endothelial cells, fibroblasts, macrophages, ciliated and nonciliated bronchial epithelial cells, smooth muscle cells, chondrocytes, and eosinophils. [2]

      • Anatomical structure: adipose_tissue

        • Eotaxin is a secretory product of adipose tissue and its expression is reversibly increased in obesity. [2]

      • Anatomical structure: epithelial_cell_with_microvilli

        • Unstimulated cells did not release detectable amounts of CCL11. [3]
        • Cytokine-stimulated alveolar type II epithelial cells express all three eotaxins and possess CCR3 receptors. [3]

        Influenced by:

        • TNFR1
          in epithelial_cell_with_microvilli

      Targets

      Reference