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Details for messenger / hormone: eotaxin-2

EndoNet ID: ENH00396

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Synonyms

  • myeloid progenitor inhibitory factor 2
  • Eot-2
  • CK-beta-6
  • small-inducible cytokine A24
  • C-C motif chemokine 24
  • CCL24
  • Ckbeta6
  • eosinophil chemotactic protein 2
  • MPIF-2
  • SCYA24
  • eotaxin-2

General information

  • Chemotactic for resting T lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3. [1]
  • TISSUE SPECIFICITY: Activated monocytes and activated T lymphocytes. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      small inducible cytokine A24

      Sequence
      VVIPSPCCM FFVSKRIPE NRVVSYQLS 
      SRSTCLKAG VIFTTKKGQ QFCGDPKQE 
      WVQRYMKNL DAKQKKASP RARAVAVKG 
      PVQRYPGNQ TTC

      Links to other resources

      UniProt O00175
      Ensembl ENST00000416943
      KEGG hsa:6369
      • Anatomical structure: monocyte

      • Anatomical structure: T-lymphocyte

      • Anatomical structure: epithelial_cell_with_microvilli

      Targets

      Reference