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Details for messenger / hormone: HCC-1

EndoNet ID: ENH00398

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Synonyms

  • NCC-2
  • HCC-1(1-74)
  • chemokine CC-1/CC-3
  • small-inducible cytokine A14
  • C-C motif chemokine 14
  • HCC-1
  • hemofiltrate CC chemokine 1
  • CCL14

General information

  • HCC-1 plays an important role in growth regulation and nucleic acids metabolism. [1]
  • Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma. [2]
  • Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. Enhances the proliferation of CD34 myeloid progenitor cells. [2]
  • The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. [2]
  • The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood. [2]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      small inducible cytokine A14

      Sequence 
      TKTESSSRG PYHPSECCF TYTTYKIPR 
QRIMDYYET NSQCSKPGI VFITKRGHS 
VCTNPSDKW VQDYIKDMK EN

      Links to other resources

      UniProt Q16627
      Ensembl ENST00000394509
      KEGG hsa:6358

      • Anatomical structure: spleen

      • Anatomical structure: skeleton_muscle

      • Anatomical structure: cardiac_muscle

      • Anatomical structure: bone_marrow

      Targets

      CellCCR1CCR3CCR5
      eosinophil granulocyte Present
      epithelial cell with microvilli Present
      lipocyte of liver Present
      Phenotypes
      • hepatic stellate cell migration
      • ERK activation
      • positive regulation of cell proliferation
      Influences
      • ↑ RANTES
      monocyte Present
      		Present
      		Present
      neutrophil granulocyte Present
      Reference