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Details for messenger / hormone: TARC

EndoNet ID: ENH00399

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Synonyms

  • small-inducible cytokine A17
  • C-C motif chemokine 17
  • TARC
  • CCL17
  • thymus and activation-regulated chemokine
  • CC chemokine TARC
  • small inducible cytokine A17

General information

  • Chemotactic factor for T lymphocytes but not monocytes or granulocytes. Binds to CCR4. [1]
  • TARC is reduced by diflorasone diacetate in the dinitrochlorobenzene model but was highly induced in the toluene-2,4-diisocyanate model. [2]
  • Expressed at high levels in thymus and at low levels in the lung, colon and small intestine. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      Sequence 
      ARGTNVGRE CCLEYFKGA IPLRKLKTW 
YQTSEDCSR DAIVFVTVQ GRAICSDPN 
NKRVKNAVK YLQSLERS

      Links to other resources

      UniProt Q92583
      Ensembl ENST00000454860
      KEGG hsa:6361

      • Anatomical structure: thymus

      • Anatomical structure: small_intestine

      • Anatomical structure: lung

      • Anatomical structure: colon

      Targets

      CellCCR4
      basophil granulocyte Present
      helper T cell Th1 Present
      platelet Present
      T-lymphocyte Present
      thymus Present
      Reference