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Details for messenger / hormone: MCP-4

EndoNet ID: ENH00400

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Synonyms

  • CK-beta-10
  • monocyte chemotactic protein 4
  • small-inducible cytokine A13
  • C-C motif chemokine 13
  • MCP-4
  • Ckbeta10
  • NCC-1
  • SCYA13
  • monocyte chemoattractant protein 4
  • CCL13

General information

  • Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and nonallergic inflammation. [1]
  • Induction: By interleukin-1 and TNF-alpha. [1]
  • Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      small inducible cytokine A13, long isoform

      • One major form (long isoform), and two minor forms (short isoform and medium isoform) are produced by differential signal cleavage. The medium isoform is about 30-fold less active than the long isoform. [1]
      Sequence 
      FNPQGLAQP DALNVPSTC CFTFSSKKI 
SLQRLKSYV ITTSRCPQK AVIFRTKLG 
KEICADPKE KWVQNYMKH LGRKAHTLK 
T

      Links to other resources

      UniProt Q99616
      Ensembl ENST00000225844
      KEGG hsa:6357

      • Anatomical structure: small_intestine

      • Anatomical structure: thymus

      • Anatomical structure: stomach

      • Anatomical structure: lymph_node

      • Anatomical structure: lung

      • Anatomical structure: colon

      • Anatomical structure: trachea

      Targets

      Reference