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Details for messenger / hormone: MPIF-1

EndoNet ID: ENH00401

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Synonyms

  • CK-beta-8
  • small-inducible cytokine A23
  • C-C motif chemokine 23
  • MPIF-1
  • Ckbeta8
  • Ckbeta8-1
  • macrophage inflammatory protein 3
  • MIP-3
  • MIP3
  • myeloid progenitor inhibitory factor 1
  • SCYA23
  • CCL23

General information

  • Shows chemotactic activity for monocytes, resting T-lymphocytes, and neutrophils, but not for activated lymphocytes. Inhibits proliferation of myeloid progenitor cells in colony formation assays. This protein can bind heparin. Binds CCR1. [1]
  • High levels in adult lung, liver, skeletal muscle and pancreas. Moderate levels in fetal liver, adult bone marrow and placenta. CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are found in high levels in synovial fluids from rheumatoid patients. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      small inducible cytokine A23 isoform CKbeta8

      • CCL23(19-99), CCL23(22-99), CCL23(27-99), CCL23(30-99) are more potent chemoattractants than the small inducible cytokine A23. [1]
      Sequence 
      RVTKDAETE FMMSKLPLE NPVLLDRFH 
ATSADCCIS YTPRSIPCS LLESYFETN 
SECSKPGVI FLTKKGRRF CANPSDKQV 
QVCMRMLKL DTRIKTRKN

      Links to other resources

      UniProt P55773
      Ensembl ENST00000293280
      KEGG hsa:6368

      • Anatomical structure: lung

      • Anatomical structure: pancreas

      • Anatomical structure: skeleton_muscle

      • Anatomical structure: placenta

      • Anatomical structure: bone_marrow

      Targets

      CellCCR1
      monocyte Present
      Reference