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Details for messenger / hormone: TECK

EndoNet ID: ENH00403

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Synonyms

  • chemokine TECK
  • thymus-expressed chemokine
  • small-inducible cytokine A25
  • C-C motif chemokine 25
  • TECK
  • thymus expressed chemokine
  • CCL25
  • small inducible cytokine A25 isoform 1

General information

  • Isoform 2 is an antagonist of isoform 1. [1]
  • Potentially involved in T cell development. Recombinant TECK shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      Sequence
      QGVFEDCCL AYHYPIGWA VLRRAWTYR 
      IQEVSGSCN LPAAIFYLP KRHRKVCGN 
      PKSREVQRA MKLLDARNK VFAKLHHNM 
      QTFQAGPHA VKKLSSGNS KLSSSKFSN 
      PISSSKRNV SLLISANSG L

      Links to other resources

      UniProt O15444-1
      Ensembl ENST00000405803
      KEGG hsa:6370
      • Anatomical structure: thymus

        • Specifically expressed by thymic dendritic cells. [1]

      Targets

      CellCCR11CCR9
      lymph node Present
      spleen Present
      thymus Present
      Reference