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Details for messenger / hormone: PARC

EndoNet ID: ENH00406

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Synonyms

  • alternative macrophage activation-associated CC chemokine 1
  • CC chemokine PARC
  • small-inducible cytokine A18
  • C-C motif chemokine 18
  • PARC
  • CCL18
  • macrophage inflammatory protein 4
  • MIP-4
  • pulmonary and activation-regulated chemokine
  • AMAC-1
  • dendritic cell chemokine 1
  • DC-CK1

General information

  • Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. Attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T cells, CD4+ and CD8+ T cells. [1]
  • Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells [1]
  • Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • chemokines
            • CC chemokines

      Composition

      small inducible cytokine A18

      Sequence 
      AQVGTNKEL CCLVYTSWQ IPQKFIVDY 
SETSPQCPK PGVILLTKR GRQICADPN 
KKWVQKYIS DLKLNA

      Links to other resources

      UniProt P55774
      Ensembl ENST00000004921
      KEGG hsa:6362

      • Anatomical structure: macrophage

        • Specifically induced in macrophages by IL-4, IL-13, and IL-10. Expression is inhibited by IFN-gamma while glucocorticoids exert a slightly positive synergistic effect in combination with IL-4. [1]

      • Anatomical structure: lung

      • Anatomical structure: lymph_node

      • Anatomical structure: placenta

      • Anatomical structure: bone_marrow

      • Anatomical structure: dendritic_cell_in_lymphoid_tissues

      Targets

      Reference