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Details for messenger / hormone: lipoprotein lipase

EndoNet ID: ENH00416

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Synonyms

  • lipoprotein lipase
  • LPL
  • LIPD

General information

  • Overexpressed in patients with type 2 diabetes.
  • The binding of leptin at the macrophage cell surface increases, through oxidative stress- and PKC-dependent pathways, LPL expression. This effect appears to be exerted at the transcriptional level and to involve AP-1 activation. [1]
  • PPAR agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages. [2]
  • Beta-cell-derived LPL has two physiologically relevant effects in islets, the inverse regulation of glucose metabolism and the independent mediation of insulin secretion through effects distal to membrane depolarization. [3]
  • Involved in lipid metabolism. [4]
  • Apolipoprotein E and lipoprotein lipase secreted from human monocyte-derived macrophages modulate very low density lipoprotein uptake. [5]
  • Lipoprotein lipase reduces secretion of apolipoprotein E from macrophages. [6]
  • Mitochondria maintain maturation and secretion of lipoprotein lipase in the endoplasmic reticulum. [7]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    Composition

    lipoprotein lipase

    Sequence 
    ADQRRDFID IESKFALRT PEDTAEDTC 
HLIPGVAES VATCHFNHS SKTFMVIHG 
WTVTGMYES WVPKLVAAL YKREPDSNV 
IVVDWLSRA QEHYPVSAG YTKLVGQDV 
ARFINWMEE EFNYPLDNV HLLGYSLGA 
HAAGIAGSL TNKKVNRIT GLDPAGPNF 
EYAEAPSRL SPDDADFVD VLHTFTRGS 
PGRSIGIQK PVGHVDIYP NGGTFQPGC 
NIGEAIRVI AERGLGDVD QLVKCSHER 
SIHLFIDSL LNEENPSKA YRCSSKEAF 
EKGLCLSCR KNRCNNLGY EINKVRAKR 
SSKMYLKTR SQMPYKVFH YQVKIHFSG 
TESETHTNQ AFEISLYGT VAESENIPF 
TLPEVSTNK TYSFLIYTE VDIGELLML 
KLKWKSDSY FSWSDWWSS PGFAIQKIR 
VKAGETQKK VIFCSREKV SHLQKGKAP 
AVFVKCHDK SLNKKSG

    Links to other resources

    UniProt P06858
    Ensembl ENST00000311322
    KEGG hsa:4023

    • Anatomical structure: adipose_tissue

    Targets

    Cell
    No records found.
    Reference