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Details for messenger / hormone: APOE

EndoNet ID: ENH00417

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Synonyms

  • APOE
  • apolipoprotein E
  • ApoE

General information

  • ApoE modulates the outcome following cerebral ischemia via molecular events in common with Alzheimer's disease pathogenesis. [1]
  • ApoE is a source of both neurotoxicity and calcium influx that involves cell surface receptors. [2]
  • ApoE is a potent growth factor in both the absence and the presence of beta-amyloid. [3]
  • ApoE exists in 3 major forms, which fiffer from each other by a substutution of one single Aminoacid. [4]
  • ApoE plays a important role in the pathogenesis of Alzheimer's disease. [5]
  • Involved in lipid metabolism. [6]

Classification

Hormone function

  • homeostasis
    • ion flow control
    • development and growth
      • growth stimulation

      Chemical classification

      • hormone
        • genome-encoded
          • apoproteins

        Composition

        Sequence 
        KVEQAVETE PEPELRQQT EWQSGQRWE 
LALGRFWDY LRWVQTLSE QVQEELLSS 
QVTQELRAL MDETMKELK AYKSELEEQ 
LTPVAEETR ARLSKELQA AQARLGADM 
EDVCGRLVQ YRGEVQAML GQSTEELRV 
RLASHLRKL RKRLLRDAD DLQKRLAVY 
QAGAREGAE RGLSAIRER LGPLVEQGR 
VRAATVGSL AGQPLQERA QAWGERLRA 
RMEEMGSRT RDRLDEVKE QVAEVRAKL 
EEQAQQIRL QAEAFQARL KSWFEPLVE 
DMQRQWAGL VEKVQAAVG TSAAPVPSD 
NH

        Links to other resources

        UniProt P02649
        Ensembl ENST00000446996
        KEGG hsa:348

        • Anatomical structure: hepatocyte

        • Anatomical structure: adipose_tissue

        • Anatomical structure: macrophage

          Influenced by:

          • ApoA-I receptor
            in macrophage
            • ApoA-I stimulates secretion of apoE from macrophage foam cells, although the mechanism of this process is not understood. [7]
            • ApoA-I stimulates secretion of apoE independently of both ABCA1-mediated cholesterol efflux and of lipid binding by its terminus. [7]

        • Anatomical structure: paraventricular_nucleus_of_hypothalamus

        • Anatomical structure: arcuate_nucleus_of_hypothalamus

        Targets

        CellLDL-RLRP1SR-BI
        hepatocyte Present
        Influences
        • ↓ apo B-48
        • ↓ apo B-100
        		Present
        Reference