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Details for messenger / hormone: osteonectin

EndoNet ID: ENH00435

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Synonyms

  • ON
  • basement-membrane protein 40
  • BM-40
  • SPARC
  • secreted protein acidic and rich in cysteine
  • osteonectin

General information

  • Secreted protein acidic and rich in cysteine/osteonectin/BM-40 is a matrix-associated protein that elicits changes in cell shape, inhibits cell-cycle progression, and influences the synthesis of extracellular matrix. [1]
  • SPARC regulates endothelial cell shape and barrier function. [2]
  • SPARC mediates lung metastasis. [3]
  • BM-40 is a modular protein composed of three independently folded domains. The N-terminal domain contains about 50 amino acids of which 18 are negatively charged. The second module is homologous to follistatin with 10 cysteines in a typical pattern. The C-terminal extracellular calcium-binding domain has two EF-hand calcium-binding motifs, each with a bound calcium ion in the x-ray structure. [4]

Classification

Hormone function

  • metabolism
    • cell metabolism

    Chemical classification

    Composition

    SPARC

    Sequence 
    APQQEALPD ETEVVEETV AEVTEVSVG 
ANPVQVEVG EFDDGAEET EEEVVAENP 
CQNHHCKHG KVCELDENN TPMCVCQDP 
TSCPAPIGE FEKVCSNDN KTFDSSCHF 
FATKCTLEG TKKGHKLHL DYIGPCKYI 
PPCLDSELT EFPLRMRDW LKNVLVTLY 
ERDEDNNLL TEKQKLRVK KIHENEKRL 
EAGDHPVEL LARDFEKNY NMYIFPVHW 
QFGQLDQHP IDGYLSHTE LAPLRAPLI 
PMEHCTTRF FETCDLDND KYIALDEWA 
GCFGIKQKD IDKDLVI
    UniProt P09486

    Osteonectin

    Sequence 
    APQEALPDE TEVVEETVA EVTEVSVGA 
NPVQVEVGE FDDGAEETE EEVVAENPC 
QNHHCKHGK VCELDENNT PMCVCQDPT 
SCPAPIGEF EKVCSNDNK TFDSSCHFF 
ATKCTLEGT KKGHKLHLD YIGPCKYIP 
PCLDSELTE FPLRMRDWL KNVLVTLYE 
RDEDNNLLT EKQKLRVKK IHENEKLLE 
AGDHPVELL ARDFEKNYN MYIFPVHWQ 
FGQLDQHPI DGYLSHTEL APLRAPLIP 
MEHCTTRLF ETCDLDNDK YIALDEWAG 
CFGIKQKDI DKDLVI

    Links to other resources

    UniProt P09486
    Ensembl ENST00000231061
    KEGG hsa:6678

    • Anatomical structure: chondrocyte

    • Anatomical structure: osteoblast

    • Anatomical structure: placenta

    • Anatomical structure: smooth_muscle_cell

    • Anatomical structure: skin

    • Anatomical structure: platelet

      • Human platelets contain and secrete osteonectin, a major protein of mineralized bone. [5]

    • Anatomical structure: endothelial_cell

      • Osteoblasts, endothelial cells, megakaryocytes, vascular smooth muscle cells, chondrocytes, steroidogenic cells, and placental trophoblasts have been described to produce osteonectin. [6]

    Targets

    Cell
    No records found.
    Reference