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Details for messenger / hormone: endothelin-1

EndoNet ID: ENH00440

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Synonyms

  • Preproendothelin-1
  • endothelin-1
  • endothelin 1
  • EDN1
  • ET-1
  • ET1
  • big endothelin-1

General information

  • Endothelin (ET)-1 is an angiogenic factor that, among others, is secreted by endothelial cells during development of several neoplasias. [1]
  • Peptide hormone that acts through G protein-coupled receptor signaling.
  • ET-1 is a potent dilator of the pulmonary vascular bed of the rat. [2]
  • Endothelin-1 is a potent 21-amino acid vasoconstrictor peptide produced by vascular endothelial cells.
  • Leptin upregulates endothelin 1, VCAM1 and MCP1. [3]
  • Oxidative stress increases synthesis of big endothelin-1 by activation of the endothelin-1 promoter. [4]
  • ET-1 regulates whole body energy metabolism through adipocyte-derived hormones. [5]
  • Big Endothelin-1 levels increase significantly in patients with various tumors, and raised plasma concentrations are associated with worse outcome. [6]

Classification

Hormone function

  • homeostasis
    • cardiovascular control

    Chemical classification

    • hormone
      • genome-encoded
        • endothelin/sarafotoxin family

      Composition

      Preproendothelin

      Sequence 
      DYLLMIFSL LFVACQGAP ETAVLGAEL 
SAVGENGGE KPTPSPPWR LRRSKRCSC 
SSLMDKECV YFCHLDIIW VNTPEHVVP 
YGLGSPRSK RALENLLPT KATDRENRC 
QCASQKDKK CWNFCQAGK ELRAEDIME 
KDWNNHKKG KDCSKLGKK CIYQQLVRG 
RKIRRSSEE HLRQTRSET MRNSVKSSF 
HDPKLKGKP SRERYVTHN RAHW

      endothelin-1

      Sequence 
      CSCSSLMDK ECVYFCHLD IIW

      Big endothelin-1

      Sequence 
      CSCSSLMDK ECVYFCHLD IIWVNTPEH 
VVPYGLGSP RS

      Links to other resources

      UniProt P05305
      Ensembl ENST00000379375
      KEGG hsa:1906

      • Anatomical structure: lung

      • Anatomical structure: sinusoidal_endothelial_cell

      • Anatomical structure: chief_cell_of_parathyroid_gland

        • Parathyroid cells express endothelin receptors and secrete ET-1 in an extracellular Ca2+ concentration dependent manner. [7]

      • Anatomical structure: umbilical_vein_endothelial_cells

        Influenced by:

        • leptin receptor isoform b
          in continuous_vascular_endothelial_cell_of_blood_vessels_and_lymphatics
          • Leptin is able to upregulate ET-1 production in human umbilical vein endothelial cells. [8]

      Targets

      CellETA-RETB-R
      bergmann glia Present
      chief cell of parathyroid gland Present
      Influences
      • ↓ PTH
      		Present
      Influences
      • ↓ PTH
      lipocyte of liver Present
      Phenotypes
      • actin-mediated cell contraction
      		Present
      Phenotypes
      • actin-mediated cell contraction
      Reference