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Details for messenger / hormone: betacellulin

EndoNet ID: ENH00442

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Synonyms

  • Probetacellulin
  • betacellulin
  • BTC

General information

  • Betacellulin is a member of the EGF family; it efficiently activates all 4 members of the ErbB receptor family, and it binds to EGFR with an affinity similar to that of EGF. [1]
  • BTC could be a strong angiogenic factor because it induces cell survival, DNA synthesis, migration, and tubule formation in endothelial cells. [1]
  • The -226A/G polymorphism of the BTC gene may contribute to the development of diabetes. [2]
  • Betacellulin belongs to the family of epidermal growth factor-like growth factors that are expressed as transmembrane precursors and undergo proteolytic ectodomain shedding to release a soluble mature growth factor. [3]
  • Betacellulin induces angiogenesis through activation of mitogen-activated protein kinase and phosphatidylinositol 3'-kinase in endothelial cell. [4]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • EGF family

      Composition

      Sequence 
      DGNSTRSPE TNGLLCGDP EENCAATTT 
QSKRKGHFS RCPKQYKHY CIKGRCRFV 
VAEQTPSCV CDEGYIGAR CERVDLFY

      Links to other resources

      UniProt P35070
      Ensembl ENST00000395743
      KEGG hsa:685

      • Anatomical structure: pancreas

      Targets

      CellADAM10EGFR isoform aErbB4
      digestive system Present
      epithelial cell Present
      epithelial cell with microvilli Present
      Influences
      • ↑ mucin-2
      G cell Present
      Influences
      • ↑ gastrin
      hepatocyte Present
      Influences
      • ↑ IL-1 alpha
      • ↑ IL-1 beta
      lipocyte of liver Present
      Phenotypes
      • positive regulation of cell proliferation and apotosis
      neutrophil granulocyte Present
      Influences
      • ↑ IL-8
      placenta Present
      Reference