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Details for messenger / hormone: NRG-3

EndoNet ID: ENH00443

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Synonyms

  • pro-neuregulin-3, membrane-bound isoform
  • NRG3
  • neuregulin-3
  • NRG-3

General information

  • Neural tissue-enriched protein that binds and activates ErbB4. [1]
  • Involved in mammary gland development and carcinogenesis. [2]
  • The expression of NRG3 is highly restricted to the developing and adult nervous system. [1]

Classification

Hormone function

  • development and growth
    • embryogenesis
      • environment adaptation

      Chemical classification

      • hormone
        • genome-encoded
          • cytokines
            • EGF family

        Composition

        neuregulin-3

        Sequence
        MSEGAAAAS PPGAASAAA ASAEEGTAA 
        AAAAAAAGG GPDGGGEGA AEPPRELRC 
        SDCIVWNRQ QTWLCVVPL FIGFIGLGL 
        SLMLLKWIV VGSVKEYVP TDLVDSKGM 
        GQDPFFLSK PSSFPKAME TTTTTTSTT 
        SPATPSAGG AASSRTPNR ISTRLTTIT 
        RAPTRFPGH RVPIRASPR STTARNTAA 
        PATVPSTTA PFFSSSTLG SRPPVPGTP 
        STQAMPSWP TAAYATSSY LHDSTPSWT 
        LSPFQDAAS SSSSSSSSA TTTTPETST 
        SPKFHTTTY STERSEHFK PCRDKDLAY 
        CLNDGECFV IETLTGSHK HCRCKEGYQ 
        GVRCDQFLP KTDSILSDP TDHLGIEFM 
        ESEEVYQR

        Links to other resources

        UniProt P56975
        Ensembl ENST00000404547
        KEGG hsa:10718

          Targets

          CellErbB4
          No records found.
          Reference