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Details for messenger / hormone: NRG-4

EndoNet ID: ENH00444

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Synonyms

  • pro-neuregulin-4, membrane-bound isoform
  • neuregulin-4
  • NRG-4

General information

  • Low affinity ligand for the ERBB4 tyrosine kinase receptor, does not bind to the ERBB1, ERBB2 and ERBB3 receptors. [1]
  • NRG-4 can displace an ErbB-4-bound NRG-1 and activate signaling downstream of this tyrosine kinase receptor. [2]

Classification

Hormone function

  • development and growth
    • growth stimulation

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • EGF family

      Composition

      Sequence
      MPTDHEEPC GPSHKSFCL NGGLCYVIP 
      TIPSPFCRC VENYTGARC EEVFLPGSS 
      IQTKSNL

      Links to other resources

      UniProt Q8WWG1
      Ensembl ENST00000394907
      KEGG hsa:145957

        Targets

        CellErbB4
        No records found.
        Reference