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Details for messenger / hormone: fibrinogen

EndoNet ID: ENH00446

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Synonyms

  • fibrinogen
  • fibrinogen alpha chain
  • fibrinopeptide A
  • FGA
  • fibrinogen A
  • fibrinogen alpha polypeptide chain

General information

  • Alternative splicing.
  • Fibrinogen is a plasma glycoprotein synthesized in the liver, composed of 3 structurally different subunits: alpha, beta, and gamma.
  • Mutations in the fibrinogen aalpha gene account for the majority of cases of congenital afibrinogenemia. [1]

Classification

Hormone function

  • immune response
    • activation

    Chemical classification

    Links to other resources

    UniProt P02671
    Ensembl ENST00000302053
    KEGG hsa:2243
    • Anatomical structure: hepatocyte

      Influenced by:

      • IL-6R
        in hepatocyte
        • We determined the role of IL-6-receptor-gp130-Stat3 signaling in IL-6 activation of the γFBG promoter in liver and lung epithelial cells. [2]
    • Anatomical structure: epithelial_cell_with_microvilli

      Influenced by:

      • IL-6R
        in epithelial_cell_with_microvilli
        • We determined the role of IL-6-receptor-gp130-Stat3 signaling in IL-6 activation of the γFBG promoter in liver and lung epithelial cells. [2]

    Targets

    Cellintegrin alpha-5/beta-1integrin alpha-IIb/beta-3vitronectin receptor
    epithelial cell Present
    macrophage Present
    Phenotypes
    • positive regulation of macrophage derived foam cell
    osteoclast Present
    Phenotypes
    • regulation of bone resorption
    Reference