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Details for messenger / hormone: vitronectin

EndoNet ID: ENH00451

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Synonyms

  • serum-spreading factor
  • VN
  • vitronectin
  • VTN
  • S-protein
  • Epibolin
  • serum spreading factor
  • V75
  • somatomedin B

General information

  • Integrin alpha V ligand.
  • Exists in two forms: a single chain 75 kDa form (V75) and a clipped form composed of two chains (65 kDa and 10 kDa) (V65+V10) which are held together by a disulfide bond. Interacts with SERPINE1/PAI1 and insulin. [1]
  • Contains somatomedin B.
  • Protease nexin-1 and plasminogen activator inhibitor-1 are serine protease inhibitors that bind to the extracellular matrix protein vitronectin with high affinity. [2]
  • Somatomedin B is a growth hormone-dependent serum factor with protease-inhibiting activity. [1]

Classification

Hormone function

  • development and growth
    • growth stimulation
    • immune response
      • activation

      Chemical classification

      Composition

      Vitronectin

      Sequence 
      DQESCKGRC TEGFNVDKK CQCDELCSY 
YQSCCTDYT AECKPQVTR GDVFTMPED 
EYTVYDDGE EKNNATVHE QVGGPSLTS 
DLQAQSKGN PEQTPVLKP EEEAPAPEV 
GASKPEGID SRPETLHPG RPQPPAEEE 
LCSGKPFDA FTDLKNGSL FAFRGQYCY 
ELDEKAVRP GYPKLIRDV WGIEGPIDA 
AFTRINCQG KTYLFKGSQ YWRFEDGVL 
DPDYPRNIS DGFDGIPDN VDAALALPA 
HSYSGRERV YFFKGKQYW EYQFQHQPS 
QEECEGSSL SAVFEHFAM MQRDSWEDI 
FELLFWGRT SAGTRQPQF ISRDWHGVP 
GQVDAAMAG RIYISGMAP RPSLAKKQR 
FRHRNRKGY RSQRGHSRG RNQNSRRPS 
RATWLSLFS SEESNLGAN NYDDYRMDW 
LVPATCEPI QSVFFFSGD KYYRVNLRT 
RRVDTVDPP YPRSIAQYW LGCPAPGHL
      UniProt P04004

      Vitronectin V65 subunit

      Sequence 
      DQESCKGRC TEGFNVDKK CQCDELCSY 
YQSCCTDYT AECKPQVTR GDVFTMPED 
EYTVYDDGE EKNNATVHE QVGGPSLTS 
DLQAQSKGN PEQTPVLKP EEEAPAPEV 
GASKPEGID SRPETLHPG RPQPPAEEE 
LCSGKPFDA FTDLKNGSL FAFRGQYCY 
ELDEKAVRP GYPKLIRDV WGIEGPIDA 
AFTRINCQG KTYLFKGSQ YWRFEDGVL 
DPDYPRNIS DGFDGIPDN VDAALALPA 
HSYSGRERV YFFKGKQYW EYQFQHQPS 
QEECEGSSL SAVFEHFAM MQRDSWEDI 
FELLFWGRT SAGTRQPQF ISRDWHGVP 
GQVDAAMAG RIYISGMAP RPSLAKKQR 
FRHRNRKGY RSQRGHSRG RNQNSRRPS 
R
      UniProt P04004

      Vitronectin V10 subunit

      Sequence 
      ATWLSLFSS EESNLGANN YDDYRMDWL 
VPATCEPIQ SVFFFSGDK YYRVNLRTR 
RVDTVDPPY PRSIAQYWL GCPAPGHL
      UniProt P04004

      Somatomedin B

      • somatomedin B is a growth hormone-dependent serum factor with protease-inhibiting activity [1]
      Sequence 
      DQESCKGRC TEGFNVDKK CQCDELCSY 
YQSCCTDYT AECKPQVT
      UniProt P04004

      Links to other resources

      UniProt P04004
      Ensembl ENST00000226218
      KEGG hsa:7448

      • Anatomical structure: osteoblast

      Targets

      Cellintegrin alpha-8/beta-1integrin alpha-V/beta-5integrin alphaV/beta3vitronectin receptor
      endothelial cell Present
      Phenotypes
      • endothelial cell adhesion
      • positive regulation of endothelial cell migration
      kidney Present
      macrophage Present
      Phenotypes
      • positive regulation of macrophage derived foam cell
      mesenchyme cell Present
      osteoclast Present
      Phenotypes
      • regulation of bone resorption
      Reference