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Details for messenger / hormone: osteopontin

EndoNet ID: ENH00453

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Synonyms

  • bone sialoprotein 1
  • urinary stone protein
  • osteopontin
  • bone sialoprotein-1
  • secreted phosphoprotein 1
  • SPP-1
  • nephropontin
  • uropontin
  • SPP1
  • OPN
  • early T lymphocyte activation 1
  • ETA1

General information

  • The synthesis of osteopontin is stimulated by calcitriol (1,25-dihydroxy-vitamin(D3), a substance that induces bone resorption. [1]
  • Ligand for integrin alpha-V/beta-3.
  • Osteopontin (OPN) is abundantly expressed in human calcified arteries. [2]
  • The cytokine osteopontin (Eta-1), which induces cellular chemotaxis, was found to be a protein ligand of CD44. [3]
  • Osteopontin (OPN) and bone sialoprotein (BSP) are bone matrix proteins that have been implicated in the selective affinity of cancer cells for bone. [4]
  • Angiotensin II and platelet-derived growth factor, two main factors involved in vessel wall pathology, also modulate OPN expression via AP-1 activation. [5]
  • Eta-1 is a key cytokine that sets the stage for efficient type-1 immune responses through differential regulation of macrophage IL-12 and IL-10 cytokine expression. [6]
  • A phosphorylation-dependent interaction between the amino-terminal portion of Eta-1 and its integrin receptor stimulated IL-12 expression, whereas a phosphorylation-independent interaction with CD44 inhibited IL-10 expression. [6]
  • Osteopontin is a phosphorylated glycoprotein secreted to the mineralizing extracellular matrix by osteoblasts during bone development. [7]
  • Phosphate is a specific signal for induction of osteopontin gene expression. [7]
  • OPN is a direct transcriptional target of TP53. [8]
  • May serve as a marker of ovarian cancer. [9]
  • Osteopontin (OPN) is encoded by the SPP1 gene, which is transcribed into three mRNA isoforms, OPN-a, -b, and -c. [10]
  • OPN is a multifunctional protein expressed in activated macrophages and T cells, osteoclasts, hepatocytes, smooth muscle, endothelial, and epithelial cells. [10]

Classification

Hormone function

  • development and growth
    • embryogenesis

    Chemical classification

    • hormone
      • genome-encoded
        • cytokines
          • osteopontin family

      Composition

      Osteopontin A, OPN-a, OP1B

      Sequence
      IPVKQADSG SSEEKQLYN KYPDAVATW 
      LNPDPSQKQ NLLAPQNAV SSEETNDFK 
      QETLPSKSN ESHDHMDDM DDEDDDDHV 
      DSQDSIDSN DSDDVDDTD DSHQSDESH 
      HSDESDELV TDFPTDLPA TEVFTPVVP 
      TVDTYDGRG DSVVYGLRS KSKKFRRPD 
      IQYPDATDE DITSHMESE ELNGAYKAI 
      PVAQDLNAP SDWDSRGKD SYETSQLDD 
      QSAETHSHK QSRLYKRKA NDESNEHSD 
      VIDSQELSK VSREFHSHE FHSHEDMLV 
      VDPKSKEED KHLKFRISH ELDSASSEV 
      N
      UniProt P10451-1

      Osteopontin B, OPN-b, OP1A

      Sequence
      MRIAVICFC LLGITCAIP VKQADSGSS 
      EEKQLYNKY PDAVATWLN PDPSQKQNL 
      LAPETLPSK SNESHDHMD DMDDEDDDD 
      HVDSQDSID SNDSDDVDD TDDSHQSDE 
      SHHSDESDE LVTDFPTDL PATEVFTPV 
      VPTVDTYDG RGDSVVYGL RSKSKKFRR 
      PDIQYPDAT DEDITSHME SEELNGAYK 
      AIPVAQDLN APSDWDSRG KDSYETSQL 
      DDQSAETHS HKQSRLYKR KANDESNEH 
      SDVIDSQEL SKVSREFHS HEFHSHEDM 
      LVVDPKSKE EDKHLKFRI SHELDSASS 
      EVN
      UniProt P10451-2

      Osteopontin C, OPN-c

      Sequence
      MRIAVICFC LLGITCAIP VKQADSGSS 
      EEKQNAVSS EETNDFKQE TLPSKSNES 
      HDHMDDMDD EDDDDHVDS QDSIDSNDS 
      DDVDDTDDS HQSDESHHS DESDELVTD 
      FPTDLPATE VFTPVVPTV DTYDGRGDS 
      VVYGLRSKS KKFRRPDIQ YPDATDEDI 
      TSHMESEEL NGAYKAIPV AQDLNAPSD 
      WDSRGKDSY ETSQLDDQS AETHSHKQS 
      RLYKRKAND ESNEHSDVI DSQELSKVS 
      REFHSHEFH SHEDMLVVD PKSKEEDKH 
      LKFRISHEL DSASSEVN
      UniProt P10451-3

      Osteopontin D

      Sequence
      MRIAVICFC LLGITCAIP VKQADSGSS 
      EEKQLYNKY PDAVATWLN PDPSQKQNL 
      LAPQNAVSS EETNDFKQE TLPSKSNES 
      HDHMDDMDD EDDDSHQSD ESHHSDESD 
      ELVTDFPTD LPATEVFTP VVPTVDTYD 
      GRGDSVVYG LRSKSKKFR RPDIQYPDA 
      TDEDITSHM ESEELNGAY KAIPVAQDL 
      NAPSDWDSR GKDSYETSQ LDDQSAETH 
      SHKQSRLYK RKANDESNE HSDVIDSQE 
      LSKVSREFH SHEFHSHED MLVVDPKSK 
      EEDKHLKFR ISHELDSAS SEVN
      UniProt P10451-4

      Osteopontin mature peptide

      Sequence
      PDAVATWLN PDPSQKQNL LAPQTLPSK 
      SNESHDHMD DMDDEDDDD HVDSQDSID 
      SNDSDDVDD TDDSHQSDE SHHSDESDE 
      LVTDFPTDL PATEVFTPV VPTVDTYDG 
      RGDSVVYGL RSKSKKFRR PDIQYPDAT 
      DEDITSHME SEELNGAYK AIPVAQDLN 
      APSDWDSRG KDSYETSQL DDQSAETHS 
      HKQSRLYKR KANDESNEH SDVIDSQEL 
      SKVSREFHS HEFHSHEDM LVVDPKSKE 
      EDKHLKFRI SHELDSASS EVN

      Links to other resources

      UniProt P10451
      Ensembl ENST00000395080
      KEGG hsa:6696
      • Anatomical structure: hepatocyte

      • Anatomical structure: chondrocyte

      • Anatomical structure: osteoblast

      • Anatomical structure: osteoclast

      • Anatomical structure: vascularendothelial_cell

      • Anatomical structure: T-lymphocyte

      • Anatomical structure: macrophage

        • Osteopontin is exceptionally highly expressed in adipose tissue macrophages in humans and mice. [10]
      • Anatomical structure: epithelial_cell

      • Anatomical structure: adipose_tissue

        • Osteopontin expression is strongly elevated in the adipose tissue (AT) of obese patients compared with lean subjects in both omental and sc AT. [10]

      Targets

      CellCD44 isoform 1integrin alpha-8/beta-1integrin alpha-9/beta-1integrin alphaV/beta3vitronectin receptor
      endothelial cell Present
      Phenotypes
      • endothelial cell adhesion
      • positive regulation of endothelial cell migration
      keratinocyte Present
      lung Present
      macrophage Present
      Phenotypes
      • positive regulation of macrophage derived foam cell
      mesenchyme cell Present
      osteoclast Present
      Phenotypes
      • regulation of bone resorption
      pancreas Present
      Reference