Details for messenger / hormone: bone sialoprotein 2

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General information
Classification

External resources
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EndoNet ID: ENH00460

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Synonyms

IBSP
bone sialoprotein 2
bone sialoprotein-2
bone sialoprotein II
BSP II
cell-binding sialoprotein
integrin-binding sialoprotein
BNSP
integrin binding sialoprotein

General information

Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. [1]
Osteopontin (OPN) and bone sialoprotein (BSP) are bone matrix proteins that have been implicated in the selective affinity of cancer cells for bone. [2]
Bone sialoprotein is one of the major noncollagenous proteins in the extracellular matrix of bone. [3]
Integrin receptor ligand that may be involved in biomineralization, induces cell adhesion, proliferation, and migration, may play a role in the metastasis of some cancers to bone.
The expression of BSP in osteoblasts is regulated directly by the RUNX2 transcription factor. [4]

Classification

Hormone function

CNS function
- learning / memory
- pain
- mood / behaviour
- circadian rhythm / sleep
- stress response
- motor activity
- neurotransmitter
homeostasis
- tissue homeostasis
- pulmonary control
- hormone precursor
- cardiovascular control
- ion flow control
- further hormone secretion
development and growth
- cancer / metastasis
- growth stimulation
- growth inhibition
- apoptosis
- embryogenesis
- environment adaptation
immune response
- activation
- inhibition
metabolism
- cell metabolism
- nutrient supply
reproduction and sexual differentiation
- sexual differentiation
- reproduction

Chemical classification

hormone
- genome-encoded
  - insulin-like growth factor binding protein related
  - IGFBP family
  - somatostatin family
  - galanin-family
  - parathyroid hormone family
  - kisspeptin family
  - GnRH family
  - peptidase S1 family
  - collagen-like domain
  - Alpha-2-macroglobulin family
  - resistin/FIZZ family
  - serpin family
  - frizzled family
  - TRH family
  - CCN family
  - antimicrobial peptides
    - alpha-defensin family
    - beta-defensin family
  - immunoglobulin superfamily
  - POMC family
  - corticotrophin-releasing factor family
  - natriuretic peptides
  - apelins
  - calcitonin family
  - Wnt family
  - peptide neurotransmitters
    - neurotensins
    - tachykinins
    - endothelins
    - neuropeptide B/W family
    - FaRP family
    - opioid neuropeptides
    - NPY family
  - chemotaxins
  - kinins
  - polyglutamine proteins
  - vasopressin/oxytocin family
  - insulin family
  - lipocalins/fatty acid-binding proteins
  - chromogranin/secretogranin family
  - thymosin beta family
  - cytokines
    - FAM3 family
    - granulin family
    - IL-1 family
    - osteopontin family
    - Leptin family
    - neuregulin-family
    - IL-10 family
    - heparin-binding growth factors
    - PDGF/VEGF growth factor family
    - IL-17 family
    - TNF family
    - EGF family
    - interferons
    - IL-6-type cytokines
    - TGF-beta family
    - chemokines
      - C chemokines
      - CXC chemokines
      - CC chemokines
  - gastrointestinal hormones
    - preprogastrin-derived peptides
      - non-classical gastrins
      - classical gastrins
    - incretins
  - apoproteins
  - small-molecule neurotransmitters
  - glucagon family
  - glycoprotein hormones family
    - stanniocalcin family
    - gonadotropic hormones
  - renin-angiotensin system
  - growth hormones
  - endothelin/sarafotoxin family
  - ephrin family
  - fetuin family
  - cystatin family
  - AVIT (prokineticin) family
  - SAA family
- not genome-encoded
  - phospholipid derivatives
  - sterol lipids
    - steroids
      - progestins
      - estrogens
      - androgens
      - mineralcorticoids
      - glucocorticoids
    - secosteroids
  - eicosanoids/fatty acid derivatives
    - hydroxy/hydroperoxyeicosatetraenoic acids
    - hydroxy/hydroperoxyeicosapentaenoic acids
    - isoprostanes
    - levuglandins
    - hepoxilins
    - lipoxins
    - leukotrienes
    - prostanoids
      - prostacyclins
      - prostaglandins
      - thromboxanes
  - amino acids
    - aspartic acids
    - glutamate-derived
    - tryptophan-derived
    - tyrosine-derived
      - catecholamines
      - thyroid hormones

Composition

Bone sialoprotein-2 chain

Sequence

FSMKNLHRR VKIEDSEEN GVFKYRPRY 
YLYKHAYFY PHLKRFPVQ GSSDSSEEN 
GDDSSEEEE EEEETSNEG ENNEESNED 
EDSEAENTT LSATTLGYG EDATPGTGY 
TGLAAIQLP KKAGDITNK ATKEKESDE 
EEEEEEEGN ENEESEAEV DENEQGING 
TSTNSTEAE NGNGSSGVD NGEEGEEES 
VTGANAEGT TETGGQGKG TSKTTTSPN 
GGFEPTTPP QVYRTTSPP FGKTTTVEY 
EGEYEYTGA NDYDNGYEI YESENGEPR 
GDNYRAYED EYSYFKGQG YDGYDGQNY 
YHHQ

UniProt

P21815

Integrin-binding sialoprotein mature peptide