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Details for messenger / hormone: atrial natriuretic factor

EndoNet ID: ENH00463

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Synonyms

  • atrial natriuretic factor
  • ANF
  • atrial natriuretic peptide
  • ANP
  • prepronatriodilatin
  • CDD-ANF
  • cardiodilatin-related peptide
  • CDP
  • NPPA
  • PND
  • Cardionatrine

General information

  • Atrial natriuretic factor (ANF) is a hormone recently shown to regulate sodium and water excretion. [1]
  • Atrial peptides also inhibit renal renin secretion and adrenal cortical secretion of aldosterone, and they oppose the vasoconstrictive action of angiotensin II. [2]
  • ANF is a circulating hormone in men and is secreted in response to isotonic volume expansion. [3]
  • The polypeptide hormone ANF is diuretic (natriuretic), hypotensive, and has an inhibitory effect on renin and aldosterone secretion. Thus, ANF probably intervenes in the short- and long-term control of water and electrolyte balance and of blood pressure. [4]
  • The ANF gene is specifically expressed in this developing chamber myocardium and is one of the first hallmarks of chamber formation. [5]

Classification

Hormone function

  • homeostasis
    • ion flow control

    Chemical classification

    • hormone
      • genome-encoded
        • natriuretic peptides

      Composition

      Cardiodilatin-related peptide

      Sequence 
      NPMYNAVSN ADLMDFKNL LDHLEEKMP 
LED
      UniProt P01160

      Atrial natriuretic factor

      Sequence 
      SLRRSSCFG GRMDRIGAQ SGLGCNSFR 
Y
      UniProt P01160

      Links to other resources

      UniProt P01160
      Ensembl ENST00000376480
      KEGG hsa:4878

      • Anatomical structure: artery

      • Anatomical structure: eye

      • Anatomical structure: kidney

      • Anatomical structure: heart

      Targets

      CellNPR1
      adrenal cortex Present
      Influences
      • ↓ aldosterone
      kidney Present
      Phenotypes
      • natriuresis
      • diuresis
      Influences
      • ↓ renin
      lung Present
      Phenotypes
      • dilation of pulmonary airways
      smooth muscle cell Present
      Phenotypes
      • vascular relaxation
      Reference