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Details for messenger / hormone: oxyntomodulin

EndoNet ID: ENH00466

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Synonyms

  • Glucagon
  • oxyntomodulin
  • OXY
  • OXM

General information

  • OXM may exert its effects on appetite via suppression of ghrelin, an orexigenic peptide produced by endocrine cells in the oxyntic glands of the stomach. [1]
  • OXM and GLP-1 promotes meal-induced insulin secretion. [1]
  • Oxyntomodulin significantly reduces food intake.
  • OXM and GLP-1 are products of the preproglucagon gene, which is expressed in the CNS, the L cells of the small intestine, and the pancreas. Preproglucagon is cleaved by prohormone convertase 1 and 2 into different products depending on the tissue. [1]
  • Increasing plasma levels of GLP-1 and OXM result in postprandial satiety. It also inhibits gastric acid secretion and motility. [1]

Classification

Hormone function

  • metabolism
    • nutrient supply

    Chemical classification

    • hormone
      • genome-encoded
        • glucagon family

      Composition

      Oxyntomodulin

      Sequence
      HSQGTFTSD YSKYLDSRR AQDFVQWLM 
      NTKRNRNNI A
      UniProt P01275

      Links to other resources

      UniProt P01275
      Ensembl ENST00000418842
      KEGG hsa:2641
      • Anatomical structure: enteroendocrine_cell_of_gastrointestinal_tract

      • Anatomical structure: nuclei_of_solitary_tract

      Targets

      CellGLP-1R
      alpha cell of islet of Langerhans Present
      Influences
      • glucagon
      beta cell of islet of Langerhans Present
      Phenotypes
      • regulation of glucose homeostasis
      • positive regulation of anti-apoptosis
      • pancreatc B cell differentiation
      • inhibition of gastric emptying
      Influences
      • insulin
      hypothalamus Present
      Phenotypes
      • reduction of food intake
      pancreas Present
      pancreatic islets Present
      proximal tubule of nephron Present
      Phenotypes
      • reduction of sodium re-absorption
      Reference